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A small revolution could be about to the hit the market in the treatment of asthma attacks: Antibiotics reduce the number of sick days of asthmatic children aged one to three years by more than 50 per cent. Read the full story at ScienceNordic

By Anne Harding January 11, 2016 NEW YORK (Reuters Health) - Azithromycin significantly shortens the duration of asthma-like episodes in young children, according to a new randomized controlled trial. "We've shown in the new study that taking out the bacteria has a very dramatic effect," Dr. Hans Bisgaard of the Copenhagen Prospective Studies of AsthmaRead more

J Allergy Clin Immunol. 2016 Jan;137(1):68-74.e4. BACKGROUND Studies of children’s blood lipid profiles in relation to asthma are few, and the results are ambiguous. OBJECTIVE We sought to examine whether the lipid profile is associated with concurrent asthma, altered lung function, and allergic sensitization in children. METHODS High-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerideRead more

J Infect Dis. 2016 Apr 15;213(8):1262-70. Wolsk HM, Følsgaard NV, Birch S, Brix S, Hansel TT, Johnston SL, Kebadze T, Chawes BL, Bønnelykke K, Bisgaard H BACKGROUND Bacterial airway colonization is known to alter the airway mucosa immune response in neonates whereas the impact of viruses is unknown. The objective was therefore to examine theRead more

Allergy. 2016 Mar;71(3):323-32. BACKGROUND First-born children are at higher risk of developing a range of immune-mediated diseases. The underlying mechanism of ‘birth-order effects’ on disease risk is largely unknown, but in utero programming of the child’s immune system may play a role. OBJECTIVE We studied the association between birth order and the functional response ofRead more

The grant was awarded to uncover the mechanisms underlying the development of childhood asthma, which today affects approximately 20% of all pre-school-age children in the westernized world. The project is based on extensive data and biological samples from 700 Danish children followed closely since the last part of their mother's pregnancy in the COPSAC (CopenhagenRead more

Prof. Bisgaard: Birth season has been reported to be a risk factor for several immune-mediated diseases, although the critical season varies depending on the disease. Autoimmune diseases are generally associated with spring births, whereas asthma and allergies are more common among subjects born in fall and winter.   Read the interview here

J Allergy Clin Immunol. 2016 Mar;137(3):844-851.e4. BACKGROUND The term atopic disorder is an early attempt to define specific endotypes of children with asthma, eczema, or both and increased IgE levels. OBJECTIVE We performed a longitudinal analysis of the relevance of the atopic endotype from birth to age 13 years. METHODS Allergic sensitization against 28 inhalant andRead more

J Allergy Clin Immunol. 2016 Apr;137(4):1026-35. den Dekker HT, Sonnenschein-van der Voort AM, de Jongste JC, Anessi-Maesano I, Arshad SH, Barros H, Beardsmore CS, Bisgaard H, Phar SC, Craig L, Devereux G, van der Ent CK, Esplugues A, Fantini MP, Flexeder C, Frey U, Forastiere F, Gehring U, Gori D, van der Gugten AC, HendersonRead more

J Allergy Clin Immunol. 2016 Apr;137(4):1238-1246.e13. BACKGROUND Birth season has been reported to be a risk factor for several immune-mediated diseases. We hypothesized that this association is mediated by differential changes in neonatal immune phenotype and function with birth season. OBJECTIVE We sought to investigate the influence of season of birth on cord blood immuneRead more