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Season of birth shapes neonatal immune function

    Home Publications Season of birth shapes neonatal immune function
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    Season of birth shapes neonatal immune function

    By COPSAC admin | Publications | Comments are Closed | 27 October, 2015 |
    J Allergy Clin Immunol. 2016 Apr;137(4):1238-1246.e13.

    BACKGROUND

    Birth season has been reported to be a risk factor for several immune-mediated diseases. We hypothesized that this association is mediated by differential changes in neonatal immune phenotype and function with birth season.

    OBJECTIVE

    We sought to investigate the influence of season of birth on cord blood immune cell subsets and inflammatory mediators in neonatal airways.

    METHODS

    Cord blood was phenotyped for 26 different immune cell subsets, and at 1 month of age, 20 cytokines and chemokines were quantified in airway mucosal lining fluid. Multivariate partial least squares discriminant analyses were applied to determine whether certain immune profiles dominate by birth season, and correlations between individual cord blood immune cells and early airway immune mediators were defined.

    RESULTS

    We found a birth season-related fluctuation in neonatal immune cell subsets and in early-life airway mucosal immune function. The seasonal airway immune pattern was associated with the number of activated and regulatory T cells in cord blood whereas it was independent of concomitant presence of pathogenic airway microbes. Specifically, summer newborns presented with the lowest levels of all cell types and mediators; fall newborns displayed high levels of activated T cells and mucosal IL-12p70, TNF-α, IL-13, IL-10, and IL-2; and winter newborns had the highest levels of innate immune cells, IL-5, type 17-related immune mediators, and activated T cells.

    CONCLUSION

    Birth season fluctuations seem to affect neonatal immune development and result in differential potentiation of cord blood immune cells and early airway mucosal immune function.

    PMID: 26581916

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    • About COPSAC
      • About
      • Organization Diagram
      • Board of Directors
      • Research team
      • Location
      • Funding
      • Logo
      • Open positions
    • COPSAC cohorts
      • COPSAC2000 cohort
      • COPSAC2010 cohort
      • COPSACSEVERE cohort
      • COPSACACUTE cohort
      • Methods
      • Data overview
        • COPSAC2000 Clinic
        • COPSAC2000 Exposures
        • COPSAC2000 Omics
        • COPSAC2000 Biobank
        • COPSAC2010 Clinic
        • COPSAC2010 Exposures
        • COPSAC2010 Omics
        • COPSAC2010 Biobank
    • Dissemination
      • Publications
      • Theses
      • Literature for parents
    • Research Projects
      • COPSYCH Research Alliance
      • HEDIMED Consortium
      • EDIAQI Consortium
      • EAGLE Consortium
      • EarlyVir
    • Strategy
    • ‌
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