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EarlyVir

  • EarlyVir
  • DSF
  • Lundbeck
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  • EAGLE Consortium
  • U-BIOPRED
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Home Home Research Clusters EarlyVir

EarlyVir - Joint Programming Initiatives

EarlyVir is a Danish, French, Canadian collaboration.

Chronic inflammatory diseases are on the rise in the westernized world, correlating to various environmental factors. Birth mode and diet are examples of environmental factors influencing early life gut microbiota (GM) colonization and maturation – and there is growing evidence that the negative effects of these factors on human health are mediated via GM alterations. We hypothesize that bacteriophages (viruses attacking bacteria) play a pivotal role in shaping the GM during early life and thus also influence risk of later disease development.

The ambitious aim of EarlyVir is to investigate how the gut virome is influenced by feeding regimes and dietary supplementation and to study the role of the early-life virome in the origins of chronic childhood disorders. The foundation of the project is the unmatched mother-child birth cohort COPSAC2010. Copenhagen Prospective studies on Asthma in Childhood (COPSAC) follows 738 unselected pregnant women and their 700 children from pregnancy week 24 and during the first 6 years of life. The mothers in COPSAC2010 were randomized to one of four groups receiving either no supplement; vitamin D, n-3 poly-unsaturated fatty acids (n-3 LCPUFA) or both during pregnancy. From this cohort we will extract intact viromes (the viral/phage GM component) from fecal samples obtained at 1 year of life; sequence, assemble and annotate the viromes; establish phage-host pairs by a cultivation-based approach and study CRISPR-Cas bacterial defense mechanisms to discover on-going phage-bacteria interactions in the gut.

The novelty of this project lies in the analysis of the early life gut virome of 700 children at the age of 1 year. Influence of diet (breast vs. formula feeding) and dietary supplementation (n-3 LCPUFA and Vitamin D) during pregnancy will be the primary focus points, but likely novel findings on the impact of birth mode (vaginal vs. cesarean section) on the gut virome might also emerge. We will examine the correlation between the early-life gut virome and disease development, focusing on asthma, eczema and allergic sensitization. This will provide key information on the role of the gut virome in disease development and will contribute to identify microbial markers predisposing for either health or disease development.

The EarlyVir Team

Top row (left-to-right)

Jonathan Thorsen, postdoc, COPSAC
Klaus Bønnelykke, Associate Professor, COPSAC
Ling Deng, Postdoc, UCPH
Mathis Hjelmsø, Postdoc, COPSAC
Moïra Dion, PhD student, ULaval
Marie-Agnes Petit, Professor, INRA
Aurelie Mathieu, Postdoc, INRA
Sylvain Moineau, Professor, ULaval

Middle row (left-to-right)

Gisle Vestergaard, Associate Professor, DTU
Emil Dalgaard, PhD studen, COPSAC
Morten Rasmussen, Associate Professor, COPSAC
Dennis Nielsen, Professor, UCPH

Bottom row (left-to-right)

Rafael Redondo, PhD studen, UCPH
Jakob Stokholm, Senior Researcher, COPSAC

Not in picture

Shiraz Shah, Senior Researcher, COPSAC
Hans Bisgaard, Professor, COPSAC
Josue Castro-Mejia, PhD student, UCPH
Søren Sørensen, Professor, UCPH
Denise Tremblay, Research Assistant, ULaval

EarlyVir Media Publicity

  • Ny forskning i virus der angriber tarmfloraens bakterier (Danish)
  • Vira kan blive fremtidens antibiotika (Danish)
  • Influence of diet on early life gut virome –  a key player in shaping the gut microbial (EarlyVir)
  • Biotechnologyfocus: Canadian microbiologist Sylvain Moineau to study the role of phages and bacteria in chronic inflammatory disease development
  • Newswire: Microbiologist Sylvain Moineau to study the role of phages and bacteria in chronic inflammatory disease development
  • Sylvain Moineau étudiera le rôle des phages et des bactéries dans le développement des maladies inflammatoires chroniques
  • Le Lezard: Le microbiologiste Sylvain Moineau étudiera le rôle des phages et des bactéries dans le développement des maladies inflammatoires chroniques

EarlyVir publications and dissemination

  • Presentation of preliminary EarlyVir results at the Centennial Celebration of Bacteriophage Research at the Pasteur Institute, Paris, 2017
    Dion, M., D. Tremblay, L. Eyrich Jessen, J. Stokholm, H. Bisgaard and S. Moineau. 2017. CRISPR as a tool to study phage-bacteria interactions in the gut. Centennial Celebration of Bacteriophage Research. April 24th – 26th. Paris, France. P-37
    View poster

CONTACT

COPSAC
Copenhagen Prospective Studies on Asthma in Childhood
Copenhagen University Hospital, Herlev-Gentofte
phone +45 3867 7360
contact@copsac.com
COPSAC • Copenhagen University Hospital, Herlev-Gentofte • Denmark © 2023
  • About COPSAC
    • Organization Diagram
    • Board of Directors
    • Research team
    • Scientific visitors
    • Hall of Fame
    • Expatriates
    • Research Students
    • Location
    • Funding
    • Press photos and logoes
    • Personal privacy policy
    • Open positions
  • COPSAC cohorts
    • COPSAC2000 cohort
    • COPSAC2010 cohort
    • COPSACSEVERE cohort
    • Available data
      • COPSAC2000 Clinic
      • COPSAC2000 Exposures
      • COPSAC2000 Omics
      • COPSAC2000 Biobank
      • COPSAC2010 Clinic
      • COPSAC2010 Exposures
      • COPSAC2010 Omics
      • COPSAC2010 Biobank
  • Dissemination
    • Publications
    • Theses
    • Research Awards and Honors
    • Literature for parents
  • Research Projects
    • COPSYCH
    • EAGLE Consortium
    • EarlyVir
  • Strategy
    • Author guidelines
  • Methods
  • ‌
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