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BMC Genet. 2011 Jul 4 Hollegaard MV1, Grove J, Grauholm J, Kreiner-Møller E, Bønnelykke K, Nørgaard M, Benfield TL, Nørgaard-Pedersen B, Mortensen PB, Mors O, Sørensen HT, Harboe ZB, Børglum AD, Demontis D, Ørntoft TF, Bisgaard H, Hougaard DM. Abstract BACKGROUND: The search to identify disease-susceptible genes requires access to biological material from numerous well-characterizedRead more

J Allergy Clin Immunol. 2011 May Bisgaard H, Pipper CB, Bønnelykke K. Abstract BACKGROUND: Asthmatic symptoms in young children reflect a heterogeneous group of diseases. Symptoms remain the primary end-point in both research and clinical management, but there is a need for standardized symptom assessment. OBJECTIVE: We sought to explore endotyping of early childhood asthmaRead more

BMC Cancer. 2011 Feb 10 Bornholdt J, Friis S, Godiksen S, Poulsen SS, Santoni-Rugiu E, Bisgaard HC, Lothe IM, Ikdahl T, Tveit KM, Johnson E, Kure EH, Vogel LK. Abstract BACKGROUND: Compromised epithelial barriers are found in dysplastic tissue of the gastrointestinal tract. Claudins are transmembrane proteins important for tight junctions. Claudins regulate the paracellularRead more

Neuropharmacology. 2011 Jan Bisgaard H1, Larsen MA, Mazier S, Beuming T, Newman AH, Weinstein H, Shi L, Loland CJ, Gether U. Abstract Analogs of benztropines (BZTs) are potent inhibitors of the dopamine transporter (DAT) but are less effective than cocaine as behavioral stimulants. As a result, there have been efforts to evaluate these compounds asRead more

Environ Res. 2011 Jan Raaschou-Nielsen O, Sørensen M, Hertel O, Chawes BL, Vissing N, Bønnelykke K, Bisgaard H. Abstract BACKGROUND: Particulate matter (PM) in ambient air is responsible for adverse health effects in adults and children. Relatively little is known about the concentrations, sources and health effects of PM in indoor air. OBJECTIVE: To identifyRead more

BMJ. 2010 Oct 4 Bisgaard H1, Hermansen MN, Bønnelykke K, Stokholm J, Baty F, Skytt NL, Aniscenko J, Kebadze T, Johnston SL. Abstract OBJECTIVE: To study the association between wheezy symptoms in young children and the presence of bacteria in the airways. DESIGN: Birth cohort study. SETTING: Clinical research unit in Copenhagen. PARTICIPANTS: Children ofRead more

Metab Brain Dis. 2010 Sep Eefsen M1, Jelnes P, Schmidt LE, Vainer B, Bisgaard HC, Larsen FS. Abstract Cerebral edema is a feared complication to acute liver failure (ALF), but the pathogenesis is still poorly understood. The water channels Aquaporin-1 (Aqp1) and -4 (Aqp4) has been associated with brain edema formation in several neuropathological conditions,Read more

Pediatr Allergy Immunol. 2010 Sep Bønnelykke K1, Pipper CB, Tavendale R, Palmer CN, Bisgaard H. Abstract Copenhagen Prospective Study on Asthma in Childhood (COPSAC) was one of the discovery cohorts of the association between eczema and variants in the filaggrin coding gene (FLG). Here, we study the FLG-associated risk of asthma symptoms in early lifeRead more

J Allergy Clin Immunol. 2010 Sep Bønnelykke K1, Pipper CB, Bisgaard H. Abstract BACKGROUND: IgE in cord blood is thought to be a product of the fetus. A high level of total IgE is therefore used as a measure of atopic propensity in the newborn. We recently found strong evidence that allergen-specific IgE in cordRead more

J Allergy Clin Immunol. 2010 Sep Chawes BL, Bønnelykke K, Kreiner-Møller E, Bisgaard H. Abstract BACKGROUND: Both allergic and nonallergic rhinitis have been associated with increased prevalence of asthma. OBJECTIVE: To characterize asthma and intermediary asthma endpoints in young children with allergic and nonallergic rhinitis. METHODS: Thirty-eight 7-year-old children with allergic rhinitis, 67 with nonallergicRead more