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J Allergy Clin Immunol. 2010 Aug Bisgaard H, Bønnelykke K. Abstract Segmentation of children with asthma and other wheezy disorders remains the main research challenge today, as it was when described 2 centuries ago. Early childhood wheezy disorders follow different temporal trajectories, probably representing different underlying mechanisms (endophenotypes). Prospective identification of endophenotypes allowing accurate predictionRead more

Chest. 2010 Aug Poorisrisak P, Halkjaer LB, Thomsen SF, Stensballe LG, Kyvik KO, Skytthe A, Schioetz PO, Bisgaard H. Abstract BACKGROUND: Respiratory syncytial virus (RSV) bronchiolitis has been associated with later development of asthma, wheezing, abnormal pulmonary function, and sensitization. Our aim was to determine the differential effect within monozygotic (MZ) twin pairs discordant forRead more

PLoS One. 2010 Jul 19 Thoren LA, Nørgaard GA, Weischenfeldt J, Waage J, Jakobsen JS, Damgaard I, Bergström FC, Blom AM, Borup R, Bisgaard HC, Porse BT. Abstract BACKGROUND: Nonsense-mediated mRNA decay (NMD) is a post-transcriptional RNA surveillance process that facilitates the recognition and destruction of mRNAs bearing premature terminations codons (PTCs). Such PTC-containing (PTC+)Read more

Am J Respir Crit Care Med. 2010 Jul 15 Chawes BL, Buchvald F, Bischoff AL, Loland L, Hermansen M, Halkjaer LB, Bønnelykke K, Bisgaard H. Abstract RATIONALE: Elevated fractional exhaled nitric oxide (Fe(NO)) concentration has been suggested to predict early childhood wheeze and sensitization. OBJECTIVES: To investigate the association between Fe(NO) in asymptomatic neonates andRead more

Chest. 2010 Jun Chawes BL1, Kreiner-Møller E, Bisgaard H. Abstract BACKGROUND: Although allergic rhinitis and asthma frequently coexist, the nature of this association is poorly understood. Therefore, we examined whether upper and lower airway patency are associated. METHODS: We investigated 221 6-year-old children from the Copenhagen Prospective Study on Asthma in Childhood birth cohort, assessingRead more

J Allergy Clin Immunol. 2010 May Brasholt M, Baty F, Bisgaard H. Abstract BACKGROUND: Physical activity is essential for young children to develop adequately and for quality of life. It can be lower in children with subclinical asthma, and therefore methods to reveal subclinical reduction in physical activity in young children are warranted. OBJECTIVE: WeRead more

Indoor Air. 2010 Apr Raaschou-Nielsen O, Hermansen MN, Loland L, Buchvald F, Pipper CB, Sørensen M, Loft S, Bisgaard H. Abstract Long-term exposure to air pollution is suspected to cause recurrent wheeze in infants. The few previous studies have had ambiguous results. The objective of this study was to estimate the impact of measured long-termRead more

J Allergy Clin Immunol. 2010 Apr Giwercman C, Halkjaer LB, Jensen SM, Bønnelykke K, Lauritzen L, Bisgaard H. Abstract BACKGROUND: Breast-feeding is recommended for the prevention of eczema, asthma, and allergy, particularly in high-risk families, but recent studies have raised concern that this may not protect children and may even increase the risk. However, diseaseRead more

Eur Respir J. 2010 Feb Smyth AR1, Barbato A, Beydon N, Bisgaard H, de Boeck K, Brand P, Bush A, Fauroux B, de Jongste J, Korppi M, O’Callaghan C, Pijnenburg M, Ratjen F, Southern K, Spencer D, Thomson A, Vyas H, Warris A, Merkus PJ. Abstract This European Respiratory Society task force has reviewed theRead more

Thorax. 2010 Feb Kindlund K, Thomsen SF, Stensballe LG, Skytthe A, Kyvik KO, Backer V, Bisgaard H. Abstract AIM: To examine the relationship between birth weight and risk of asthma in a population of twins. METHODS: Birth weight of all live twins (8280 pairs) born in Denmark between 1994 and 2000 was linked to informationRead more