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2021 Anders Eliasen – MSc

  • 2021 Sarah Nørgaard – MSc
  • 2019 Christian Carlsson, MD
  • 2019 Ni Wang, MD
  • 2021 Lærke Sass – MD
  • 2021 Anders Eliasen – MSc
  • 2021 Nicklas Brustad – MD
  • 2018 Nadia Rahman Fink, MD
  • 2015 Ann-Marie Malby Schoos, MD PhD
    • Thesis_2015_Ann-Marie_Schoos
  • 2014 Marie Kragh, MSc PhD
    • Thesis_2014_Marie-Kragh.pdf
  • 2014 Eskil Kreiner-Møller, MD PhD
    • Thesis_2014_Eskil-Kreiner-Moller
  • 2014 Nadja Hawwa Vissing, MD PhD
    • Thesis_2014_Nadja-Vissing
  • 2014 Anna Hammerich Thysen, Msc PhD
    • Thesis_2014_Anna-Thysen
  • 2013 Charlotte Giwercman Carson MD, PhD
    • Thesis_2013_Charlotte-Giwercman
  • 2013 Anne Louise Bischoff MD, PhD
    • Thesis_2013_Anne-Bischoff
  • 2012 Louise Pedersen, MD, PhD
    • Thesis_2012_Louise-Pedersen
  • 2012 Jakob Stokholm, MD, PhD
    • Thesis_2012_Jakob-Stokholm
  • 2012 Nilofar Følsgaard, MD, PhD
    • Thesis_2012_Nilo-Foelsgaard
  • 2011 Martin Brasholt, MD, PhD
    • Thesis_2011_Martin-Brasholt
  • 2011 Bo Chawes, MD, PhD
    • Thesis_2011_Bo-Chawes
  • 2010 Klaus Bønnelykke, MD, PhD
    • Thesis_2010_Klaus-Bonnelykke
  • 2010 Porntiva Poorisrisak, MD, PhD
    • Thesis_2010_Porntiva-Poorisrisak
  • 2009 Mette N Hermansen, MD, PhD
    • Thesis_2009_Mette-Hermansen
  • 2006 Liselotte B Halkjær, MD, PhD
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  • 2006 Birgitte Boysen Kjær, MD, PhD
  • 2004 Lotte Loland, MD, PhD
    • Thesis_2004_Lotte-Loland
  • 2002 Frederik F Buchvald, MD, PhD
    • Thesis_2002_Frederik-Buchvald
  • 1999 Marianne Stubbe Østergaard, MD, PhD
  • 1993 Jytte Fogh, MD, PhD
  • 2020 Asja Kunøe – MD
  • 2017 Elín Bjarnadóttir, MD PhD
  • 2019 Christian Carlsson, MD
  • 2017 Helene Wolsk, MD
  • 2019 Lambang Arianto, MD
  • 2018 Henrik Hallas, MD
  • 2018 Jonathan Thorsen, MD
  • 2017 Tine Marie Pedersen, MD
  • 2017 Astrid Sevelsted, MSc
  • 2017 Rebecca Kofod Vinding, MD
Home Home Dissemination Theses 2021 Anders Eliasen – MSc

Analysis of epistasis in childhood asthma

By Anders Ulrik Eliasen

Summary

Chair persons: Elena Papaleo and Morten Nielsen

Opponent: Marie Standl

Opponent: Anders Albrechtsen

ABSTRACT

Despite years of research, scientists have yet to fully unravel the intricate relationship between variations in the genome and trait variation. Genome- wide association studies (GWAS) have successfully identified thousands of susceptibility genes for human traits. However, these genes do not explain the complete trait heritability, indicating that there is still important unidenti- fied genetic variation. A controversial phenomenon within GWAS is genetic interactions. Genetic interactions have proven to be very elusive and diffi- cult to identify, why it remains mostly speculation as to whether they have a place in the genetic architecture of human traits.

This thesis presents research conducted within genetic association studies, specifically focusing on identifying and understanding genetic interactions in childhood asthma. The structure of the thesis includes six chapters cov- ering introduction, research hypothesis and aims, material and methods, re- sults, discussion, and conclusion. Throughout the thesis, I will use the plural personal pronoun “we” when discussing scientific papers and the underlying methodology, as this work has been a collaborative effort. The term “I” will be used when describing my own views.

The primary results of the thesis consist of two scientific papers, which are listed below. The chapters before the results describe a selection of the un- derlying theory, applied statistical methods, and data used for the analysis. The author contributions and title for the two papers are listed below:

Paper I: Tarunveer S. Ahluwalia* Anders U. Eliasen*, Astrid Sevel- sted, Casper-Emil T. Pedersen, Jakob Stokholm, Bo Chawes, Jette Bork- Jensen, Niels Grarup, Oluf Pedersen, Torben Hansen , Allan Linneberg, Amitabh Sharma, Scott T. Weiss, Michael D. Evans, Daniel J. Jackson, Andreanne Morin, Karen A. Krogfelt, Susanne Schjørring, Preben B. Mortensen, David M. Hougaard, Jonas Bybjerg-Grauholm, Marie Bækvad- Hansen, Ole Mors, Merete Nordentoft, Anders D. Børglum, Thomas Werge, Esben Agerbo, James E. Gern, Robert F. Lemanske Jr., Carole Ober, Anders G. Pedersen, Hans Bisgaard, Klaus Bønnelykke

*these authors contributed equally

FUT2-ABO epistasis increases the risk of ealy childhood asthma and Streptococcus pneumonia infections
Nature communications (2020)

Paper II: Anders U. Eliasen, Casper Emil T. Pedersen, Morten A. Ras- mussen, Ni Wang, Matteo Soverini, Amelie Fritz, Jakob Stokholm, Bo L. Chawes, Andreanna Morin, Jette Bork-Jensen, Niels Grarup, Oluf Ped- ersen, Torben Hansen, Allan Linneberg, Preben B. Mortensen, David M. Hougaard, Jonas Bybjerg-Grauholm, Marie Bækvad-Hansen, Ole Mors, Merete Nordentoft, Anders D. Børglum, Thomas Werge, Esben Agerbo, Cilla Söderhall, Matthew C. Altman, Anna H. Thysen, Susanne Brix, James E. Gern, Carole Ober, Tarunveer S. Ahluwalia, Hans Bisgaard, Anders G. Pedersen*, Klaus Bønnelykke*

*these authors contributed equally

Genome-wide study of early childhood asthma with severe exacer- bations identifies epistasis between CDHR3 and GSDMB Submitted (2021)


CONTACT

COPSAC
Copenhagen Prospective Studies on Asthma in Childhood
Copenhagen University Hospital, Herlev-Gentofte
phone +45 3867 7360
contact@copsac.com
COPSAC • Copenhagen University Hospital, Herlev-Gentofte • Denmark © 2022
  • About COPSAC
    • Organization Diagram
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  • COPSAC cohorts
    • COPSAC2000 cohort
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    • Available data
      • COPSAC2000 Clinic
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  • Dissemination
    • Publications
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    • Research Awards and Honors
    • Literature for parents
  • Research Clusters
    • COPSYCH
    • EAGLE Consortium
    • EarlyVir
  • Strategy
    • Author guidelines
  • Methods
  • ‌
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