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Studies on hepatic gene expression in different liver regenerative models.

    Home Publications Studies on hepatic gene expression in different liver regenerative models.
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    Studies on hepatic gene expression in different liver regenerative models.

    By Dansk Børne Astma Center | Publications | Comments are Closed | 7 June, 2000 |

    Biochem Biophys Res Commun. 2000 Jun 7
    Nagy P, Bisgaard HC, Schnur J, Thorgeirsson SS.

    Abstract
    We have investigated the expression of several growth-related genes in the liver after partial hepatectomy in three experimental models: normal, Dexamethasone-pretreated, and hypophysectomized rats. Dexamethasone and hypophysectomy resulted in a delay in the peak of cell replication in 6 and 18 h, respectively, when compared to the normal animals. TGFalpha mRNA expression was shifted together with the DNA synthesis, but the expression of c-myc, c-fos, c-jun, HGF, TGFbeta1, IL1beta did not delay. This result suggests that liver-derived TGFalpha but not the other factors are important in the timing of the proliferative response after partial hepatectomy.

    Copyright 2000 Academic Press.

    PMID: 10833457

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