Pediatrics. 2008 Mar
Thomsen SF, Stensballe LG, Skytthe A, Kyvik KO, Backer V, Bisgaard H.
Abstract
OBJECTIVE:
We estimated differences in the severity of respiratory syncytial virus infection attributable to genetic and environmental factors.
METHODS:
Record linkage data on hospitalizations attributable to respiratory syncytial virus infection were gathered on all twins (12,346 pairs) born in Denmark between 1994 and 2003. Latent-factor models of genetic and environmental effects were fitted to the observed data by using maximal likelihood methods.
RESULTS:
Identical twins resembled each other significantly more than did fraternal twins for respiratory syncytial virus hospitalization (concordance rate: 0.66 vs 0.53), which suggests genetic influences on disease severity. Genetic factors accounted for 16%, family environment for 73%, and nonshared environment for 11% of the individual susceptibility to develop severe respiratory syncytial virus infection.
CONCLUSIONS:
The severity of respiratory syncytial virus infection is determined partly by genetic factors. This result should stimulate the search for genetic markers of disease severity.
PMID: 18310197
