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Pediatr Pulmonol. 1997 Apr Klug B, Bisgaard H. Abstract To determine the repeatability of bronchial responsiveness in awake young children, two methacholine challenge tests were performed on separate days in 16 children with stable asthma (mean age, 3 3/4 years). Methacholine was administered using a new method for quantitative delivery of aerosol that eliminates theRead more

Invasion Metastasis. 1997 Bisgaard HC, Mackay AR, Gomez DE, Ton PT, Thorgeirsson SS, Thorgeirsson UP. Abstract Cloned v-raf, v-raf/v-myc, and spontaneously transformed rat liver epithelial (RLE) cell lines were examined for meastatic capability in nude mice, using the LacZ gene as a marker for quantitation of micrometastases. Six cloned lines (R3611-T lines) derived from nudeRead more

Invasion Metastasis. 1997 Bisgaard HC1, Mackay AR, Gomez DE, Ton PT, Thorgeirsson SS, Thorgeirsson UP. Abstract Cloned v-raf, v-raf/v-myc, and spontaneously transformed rat liver epithelial (RLE) cell lines were examined for meastatic capability in nude mice, using the LacZ gene as a marker for quantitation of micrometastases. Six cloned lines (R3611-T lines) derived from nudeRead more

Eur Respir J. 1995 Dec Bisgaard H, Klug B. Abstract The aim of the study was to evaluate methods applicable in a clinical setting for monitoring of changes in lung function in awake young children. Impedance measurements by the impulse oscillation technique (ZIOS), respiratory resistance measurements by the interrupter technique (Rint) and transcutaneous measurements ofRead more

Acta Paediatr. 1996 Jun Daugbjerg P, Nielsen KG, Skov M, Bisgaard H. Abstract The aim of this study was to evaluate the effect and tolerability of formoterol 12 micrograms on exercise-induced asthma in children for 12 h as compared to the effect of salbutamol 400 micrograms and placebo. The drugs were inhaled as dry powderRead more

Acta Paediatr. 1996 Jun Daugbjerg P, Nielsen KG, Skov M, Bisgaard H. Abstract The aim of this study was to evaluate the effect and tolerability of formoterol 12 micrograms on exercise-induced asthma in children for 12 h as compared to the effect of salbutamol 400 micrograms and placebo. The drugs were inhaled as dry powderRead more

Arch Dis Child. 1996 May Nysom K, Holm K, Hesse B, Ulrik CS, Jacobsen N, Bisgaard H, Hertz H. Abstract Longitudinal data were analysed on the lung function of 25 of 29 survivors of childhood leukaemia or lymphoma, who had been conditioned with cyclophosphamide and total body irradiation before allogeneic bone marrow transplantation, to testRead more

Pediatr Pulmonol. 1996 May;21(5):290-300. Klug B1, Bisgaard H. Abstract This study evaluated three techniques for testing of lung function in young awake children. We compared measurements by the forced or impulse oscillation technique (IOS), the interrupter technique (IT), and transcutaneous measurements of oxygen (tcPo2) with concomitant measurements of specific airway resistance (sRaw) during methacholine challengeRead more

Eur Respir J Suppl. 1996 Apr Bisgaard H1, Pedersen S. Abstract Data concerning safety of treatment in schoolchildren cannot be extrapolated to preschool children due to differences in growth velocity and metabolism. The safety issue in preschool children is further complicated by insufficient knowledge of the optimal dose, and the lung delivery from the devicesRead more

Hepatology. 1996 Jan Bisgaard HC, Nagy P, Santoni-Rugiu E, Thorgeirsson SS. Abstract In this study, we used [3H]thymidine labeling of newly synthesized DNA to examine the earliest effects of 2-acetylaminofluorene (2-AAF) on the mitotic activation of cells in the adult rat liver, and in situ hybridization analysis to study the expression of three transcription factorsRead more