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Clin Microbiol Infect. 2014 Jul Stokholm J1, Schjørring S, Eskildsen CE, Pedersen L, Bischoff AL, Følsgaard N, Carson CG, Chawes BL, Bønnelykke K, Mølgaard A, Jacobsson B, Krogfelt KA, Bisgaard H. Abstract Antibiotics may induce alterations in the commensal microbiota of the birth canal in pregnant women. Therefore, we studied the effect of antibiotic administrationRead more

PLoS One. 2014 Jun 12 Chawes BL, Bønnelykke K, Jensen PF, Schoos AM, Heickendorff L, Bisgaard H. Abstract BACKGROUND: Epidemiological studies have suggested an association between maternal vitamin D dietary intake during pregnancy and risk of asthma and allergy in the offspring. However, prospective clinical studies on vitamin D measured in cord blood and developmentRead more

J Allergy Clin Immunol. 2014 May Sonnenschein-van der Voort AM, Arends LR, de Jongste JC, Annesi-Maesano I, Arshad SH, Barros H, Basterrechea M, Bisgaard H, Chatzi L, Corpeleijn E, Correia S, Craig LC, Devereux G, Dogaru C, Dostal M, Duchen K, Eggesbø M, van der Ent CK, Fantini MP, Forastiere F, Frey U, Gehring U,Read more

Clin Exp Allergy. 2014 Apr Bisgaard H1, Bønnelykke K, Stokholm J. Abstract The non-communicable disease pandemic includes immune-mediated diseases such as asthma and allergy, which are likely originating in early life where the immature immune system is prone to alterations caused by the exposome. The timing of exposure seems critical for the developing immune system,Read more

J Allergy Clin Immunol. 2014 Apr Larsen JM, Brix S, Thysen AH, Birch S. Rasmussen MA, Bisgaard H. Abstract BACKGROUND: Asthma is a highly prevalent chronic lung disease that commonly originates in early childhood. Colonization of neonatal airways with the pathogenic bacterial strains Haemophilus influenzae, Moraxella catarrhalis, and Streptococcus pneumoniae is associated with increased riskRead more

Eur Respir J. 2014 Mar Mortensen LJ1, Kreiner-Møller E, Hakonarson H, Bønnelykke K, Bisgaard H. Abstract Previous studies have suggested that variants in the protocadherin-1 (PCDH1) gene, which is important for cell-cell adhesion, are associated with asthma, bronchial, hyperresponsiveness and atopic dermatitis in school children. Our aim was to associate common variants of the PCDH1Read more

Nat Genet. 2014 Jan Bønnelykke K, Sleiman P, Nielsen K, Kreiner-Møller E, Mercader JM, Belgrave D, den Dekker HT, Husby A, Sevelsted A, Faura-Tellez G, Mortensen LJ, Paternoster L, Flaaten R, Mølgaard A, Smart DE, Thomsen PF, Rasmussen MA, Bonàs-Guarch S, Holst C, Nohr EA, Yadav R, March ME, Blicher T, Lackie PM, Jaddoe VW,Read more

Fibrogenesis Tissue Repair. 2013 Dec Vestentoft PS, Jelnes P, Andersen JB, Tran TA, Jørgensen T, Rasmussen M, Bornholdt J, Grøvdal LM, Jensen CH, Vogel LK, Thorgeirsson SS, Bisgaard HC. Abstract BACKGROUND: Tissue repair in the adult mammalian liver occurs in two distinct processes, referred to as the first and second tiers of defense. We undertookRead more

PLoS One. 2013 Dec 10 Stokholm J1, Schjørring S, Pedersen L, Bischoff AL, Følsgaard N, Carson CG, Chawes BL, Bønnelykke K, Mølgaard A, Krogfelt KA, Bisgaard H. Abstract BACKGROUND: Antibiotic treatment during pregnancy and birth is very common. In this study, we describe the estimated prevalence of antibiotic administration during pregnancy and birth in theRead more

Clin Exp Allergy. 2013 Dec Bisgaard H1, Vissing NH, Carson CG, Bischoff AL, Følsgaard NV, Kreiner-Møller E, Chawes BL, Stokholm J, Pedersen L, Bjarnadóttir E, Thysen AH, Nilsson E, Mortensen LJ, Olsen SF, Schjørring S, Krogfelt KA, Lauritzen L, Brix S, Bønnelykke K. Abstract BACKGROUND: We hypothesize that perinatal exposures, in particular the human microbiomeRead more