Chest. 2001 Dec
Bisgaard H, Price MJ, Maden C, Olsen NA.
Abstract
STUDY OBJECTIVES:
To evaluate the cost-effectiveness of inhaled fluticasone propionate (FP) in children aged 12 to 47 months with asthma symptoms.
DESIGN:
A retrospective economic analysis conducted from the perspective of the Danish health-care system, based on clinical data from a 12-week study.
SETTING:
Thirty-three outpatient centers in nine countries.
PATIENTS:
Two hundred thirty-seven children aged 12 to 47 months with documented history of recurrent wheeze or asthma symptoms.
INTERVENTIONS:
Two dosages of FP, 100 microg/d and 200 microg/d, and placebo administered in two divided doses via a metered-dose inhaler and a Babyhaler (Glaxo Wellcome; Middlesex, UK) spacer device.
MEASUREMENTS:
Effectiveness in terms of asthma exacerbations, control of cough and wheeze symptoms, symptom-free days, overall direct costs of asthma management in Danish kroner at 1999 prices, and mean and incremental cost-effectiveness ratios.
RESULTS:
FP, 200 microg/d, was significantly more effective than placebo treatment in terms of the proportion of exacerbation-free patients (73.7% vs 59.8%; p = 0.025) and patients experiencing a > or = 25% improvement in cough symptoms (57.9% vs 39.0%; p = 0.018). The costs per exacerbation-free patient, per patient with a > or = 25% improvement in cough and wheeze symptoms from baseline, and per symptom-free day were lower in the FP groups than in the placebo group. The incremental cost-effectiveness ratios for these end points indicated that the additional benefits of FP, 200 microg/d, were achieved at a lower overall cost compared with placebo treatment.
CONCLUSIONS:
From the perspective of the Danish health-care system, FP, 100 microg bid, administered via the Babyhaler inhalation device was cost-effective
relative to standard therapy with bronchodilators alone.
Comment in
Pharmacoeconomics in pediatric asthma. [Chest. 2001]
Fluticasone vs placebo in toddlers with asthma: good science or questionable ethics? [Chest. 2002]
PMID: 11742910
