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Clin Exp Allergy. 2016 Jan;46(1):112-24. BACKGROUND Viral respiratory infections can cause acute wheezing illnesses in children and exacerbations of asthma. OBJECTIVE We sought to identify variation in genes with known antiviral and pro-inflammatory functions to identify specific associations with more severe viral respiratory illnesses and the risk of virus-induced exacerbations during the peak fall season.Read more

J Allergy Clin Immunol. 2016 Jan Vinding RK, Stokholm J, Chawes BL, Bisgaard H. Abstract BACKGROUND: Studies of children’s blood lipid profiles in relation to asthma are few, and the results are ambiguous. OBJECTIVE: We sought to examine whether the lipid profile is associated with concurrent asthma, altered lung function, and allergic sensitization in children.Read more

J Allergy Clin Immunol. 2016 Jan;137(1):68-74.e4. BACKGROUND Studies of children’s blood lipid profiles in relation to asthma are few, and the results are ambiguous. OBJECTIVE We sought to examine whether the lipid profile is associated with concurrent asthma, altered lung function, and allergic sensitization in children. METHODS High-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerideRead more

Clin Exp Allergy. 2016 Jan Loisel DA, Du G, Ahluwalia TS, Tisler CJ, Evans MD, Myers RA, Gangnon RE, Kreiner-Møller E, Bønnelykke K, Bisgaard H, Jackson DJ, Lemanske RF Jr, Nicolae DL, Gern JE, Ober C. Abstract BACKGROUND: Viral respiratory infections can cause acute wheezing illnesses in children and exacerbations of asthma. OBJECTIVE: We soughtRead more

J Infect Dis. 2016 Apr 15;213(8):1262-70. Wolsk HM, Følsgaard NV, Birch S, Brix S, Hansel TT, Johnston SL, Kebadze T, Chawes BL, Bønnelykke K, Bisgaard H BACKGROUND Bacterial airway colonization is known to alter the airway mucosa immune response in neonates whereas the impact of viruses is unknown. The objective was therefore to examine theRead more

Nat Genet. 2015 Dec Paternoster L, Standl M, Waage J, Baurecht H, Hotze M, Strachan DP, Curtin JA, Bønnelykke K, Tian C, Takahashi A, Esparza-Gordillo J, Alves AC, Thyssen JP, den Dekker HT, Ferreira MA, Altmaier E, Sleiman PM, Xiao FL, Gonzalez JR, Marenholz I, Kalb B, Pino-Yanes M, Xu CJ, Carstensen L, Groen-Blokhuis MM,Read more

Allergy. 2016 Mar;71(3):323-32. BACKGROUND First-born children are at higher risk of developing a range of immune-mediated diseases. The underlying mechanism of ‘birth-order effects’ on disease risk is largely unknown, but in utero programming of the child’s immune system may play a role. OBJECTIVE We studied the association between birth order and the functional response ofRead more

J Allergy Clin Immunol. 2015 Nov Jelding-Dannemand E, Malby Schoos AM, Bisgaard H. Abstract BACKGROUND: Extended breast-feeding is recommended for newborn children at risk of allergy-associated diseases, but the evidence of a protective effect on sensitization and these diseases remains elusive. OBJECTIVE: The aim of this study was to investigate the effects of the durationRead more

J Allergy Clin Immunol. 2016 Mar;137(3):844-851.e4. BACKGROUND The term atopic disorder is an early attempt to define specific endotypes of children with asthma, eczema, or both and increased IgE levels. OBJECTIVE We performed a longitudinal analysis of the relevance of the atopic endotype from birth to age 13 years. METHODS Allergic sensitization against 28 inhalant andRead more

J Allergy Clin Immunol. 2015 Nov Carlsson CJ, Vissing NH, Sevelsted A, Johnston SL, Bønnelykke K, Bisgaard H. Abstract BACKGROUND: Wheezy episodes in young children are often triggered by viral and bacterial respiratory tract infections, but there is little evidence supporting the hypothesis that symptom duration depends on the specific microbial trigger. OBJECTIVE: We soughtRead more