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Paediatr Respir Rev. 2005 Dec Nielsen KG, Bisgaard H. Abstract Important asthma outcomes such as lung function and bronchial hyperresponsiveness are probably determined in early childhood. Early and longitudinal objective assessment of lung function and bronchial hyperresponsiveness is necessary to enable early diagnosis, monitor intervention and improve prognosis in preschool children. Cold air challenge andRead more

APMIS. 2005 Nov-Dec Santoni-Rugiu E, Jelnes P, Thorgeirsson SS, Bisgaard HC. Abstract Although normally quiescent, the adult mammalian liver possesses a great capacity to regenerate after different types of injuries in order to restore the lost liver mass and ensure maintenance of the multiple liver functions. Major players in the regeneration process are mature residualRead more

Chest. 2005 Oct Buchvald F, Hermansen MN, Nielsen KG, Bisgaard H. Abstract BACKGROUND: Exercise-induced bronchoconstriction (EIB) is of particular importance in children with asthma. It is an important measure of asthma control and should be monitored by exercise testing. However, exercise testing puts a large demand on health-care resources and is therefore not widely usedRead more

Pediatr Pulmonol. 2005 Jul Santanello NC, Norquist JM, Nelsen LM, Williams VS, Hill CD, Bisgaard H. Abstract Acute respiratory syncytial virus (RSV)-induced bronchiolitis is often associated with continuing respiratory symptoms following hospitalization. To date, there is no validated objective measure to evaluate symptoms of RSV-induced bronchiolitis. We report on the reliability, validity, and responsiveness ofRead more

Chest. 2005 Jul Bisgaard H, Nielsen KG. Abstract Validated methods for lung function measurements in young children are lacking. Plethysmographic measurement of specific airway resistance (sRaw) provides such a method applicable from 2 years of age. sRaw gauges airway resistance from the measurements of the pressure changes driving the airflow during tidal breathing. These measurementsRead more

J Allergy Clin Immunol. 2005 Jun Buchvald F, Baraldi E, Carraro S, Gaston B, De Jongste J, Pijnenburg MW, Silkoff PE, Bisgaard H. Abstract BACKGROUND: Fractional exhaled nitric oxide (FE NO ) is used in monitoring of asthma. OBJECTIVES: The aim of this multicenter study was to establish normal values of FE NO and assessRead more

J Allergy Clin Immunol. 2005 Apr Bisgaard H1, Szefler SJ. Abstract Limitations in asthma prevalence studies and difficulties in diagnosing pediatric asthma lead to uncertainty over the full extent of mild persistent asthma in children and adolescents. Although recent surveys have reported that the majority of pediatric patients with asthma in the United States andRead more

Allergy. 2005 Mar Sazonov Kocevar V, Thomas J 3rd, Jonsson L, Valovirta E, Kristensen F, Yin DD, Bisgaard H. Abstract BACKGROUND: Preliminary evidence suggests that inadequately controlled allergic rhinitis in asthmatic patients can contribute towards increased asthma exacerbations and poorer symptom control, which may increase medical resource use. The objective of this study was thereforeRead more

Am J Respir Crit Care Med. 2005 Feb 15 Bisgaard H, Zielen S, Garcia-Garcia ML, Johnston SL, Gilles L, Menten J, Tozzi CA, Polos P. Abstract The PREVIA study was designed to investigate the role of montelukast, a leukotriene receptor antagonist, in the prevention of viral-induced asthma exacerbations in children aged 2 to 5 yearsRead more

Am J Respir Crit Care Med. 2005 Feb 1 Nielsen KG1, Bisgaard H. Abstract Cold air challenge (CACh) has been shown to discriminate between children with asthma and healthy young children. Hyperventilation with dry room-temperature air is a simplified alternative. We compared responsiveness in young children with asthma between two standardized, single-step protocols: dry airRead more