The COPSAC2000 cohort
The COPSAC2000 cohort is a prospective clinical mother-child cohort study of 411 children of asthmatic mothers. The study is designed to assess gene-environment interactions in the origin of atopic diseases with an aim to identify early-life exposures that can be modified to improve preventive strategies. The children attend the COPSAC clinical research unit from birth till adolescence at six-monthly intervals for scheduled clinical investigations according to standard operating procedures, and additional visits are arranged at onset of any respiratory or skin symptom. Clinical outcomes comprise pre-asthma, asthma, eczema, allergic rhinitis, allergy, lung function, bronchial responsiveness and respiratory infections. Exposure assessments comprise respiratory, intestinal and skin microbiology; the child’s diet; indoor and outdoor air quality; allergens; and indicators of life style. Genetic analysis of both children and their parents is performed.
See details on the cohort at birthcohorts.net