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Author Carlsen, K.; Pedersen, L.; Bonnelykke, K.; Stark, K.D.; Lauritzen, L.; Bisgaard, H. url  doi
  Title Association between whole-blood polyunsaturated fatty acids in pregnant women and early fetal weight Type Journal Article
  Year (down) 2013 Publication European Journal of Clinical Nutrition Abbreviated Journal Eur J Clin Nutr  
  Volume 67 Issue 9 Pages 978-983  
  Keywords Birth Weight/drug effects; Body Height/drug effects; Body Mass Index; Fatty Acids, Omega-3/*blood; Fatty Acids, Omega-6/*blood; Female; Femur/drug effects/growth & development; Fetal Weight/*drug effects; Gestational Age; Humans; Linear Models; Pregnancy; Prospective Studies; Weight Gain/drug effects  
  Abstract BACKGROUND/OBJECTIVES: Studies suggest that intake of marine n-3 polyunsaturated fatty acids (n-3 PUFA) in pregnancy have an impact on birth weight, but only few have investigated the effect on early fetal growth. The objective of the study was to investigate the association between levels of PUFA in maternal blood in gestational week 24 and biometric measures and estimated fetal weight in gestational week 20. SUBJECTS/METHODS: In the COPSAC2010 cohort, whole-blood fatty acid composition (a biomarker of PUFA intake) from 583 women in week 24 was analyzed by gas chromatography. Biometric data (head circumference, abdominal circumference and femur length) were collected by ultra sound in week 20 and fetal weight was estimated. Associations between whole-blood PUFA (docosahexaenoic acid (DHA), total n-3 PUFA, n-6/n-3 PUFA, total n-6 PUFA) and fetal weight and biometrics measures were analyzed by multivariable-adjusted linear regression analyses. RESULTS: There was a wide range in maternal blood DHA, which varied from 1.8 to 6.9% depending on socioeconomic status, smoking and body mass index. After adjusting for these variables, no association was observed between any of the assessed PUFA components and the circumference of head or abdomen or fetal weight. However, an inverse association was established between DHA and total n-3 PUFA and femur length (P<0.02). CONCLUSION: Maternal whole-blood PUFA composition, specifically her n-3 PUFA status, in gestational week 24 was not associated with overall early fetal weight gain, but this study indicates that it may decrease the length of femur.  
  Address Copenhagen University Hospital Gentofte, Gentofte, Denmark.  
  Corporate Author Thesis  
  Impact Factor 02,709 First Author Carlsen, K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0954-3007 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23756387 Approved no  
  Call Number Serial 99  
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