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Author Bonnelykke, K.; Matheson, M.C.; Pers, T.H.; Granell, R.; Strachan, D.P.; Alves, A.C.; Linneberg, A.; Curtin, J.A.; Warrington, N.M.; Standl, M.; Kerkhof, M.; Jonsdottir, I.; Bukvic, B.K.; Kaakinen, M.; Sleimann, P.; Thorleifsson, G.; Thorsteinsdottir, U.; Schramm, K.; Baltic, S.; Kreiner-Moller, E.; Simpson, A.; St Pourcain, B.; Coin, L.; Hui, J.; Walters, E.H.; Tiesler, C.M.T.; Duffy, D.L.; Jones, G.; Ring, S.M.; McArdle, W.L.; Price, L.; Robertson, C.F.; Pekkanen, J.; Tang, C.S.; Thiering, E.; Montgomery, G.W.; Hartikainen, A.-L.; Dharmage, S.C.; Husemoen, L.L.; Herder, C.; Kemp, J.P.; Elliot, P.; James, A.; Waldenberger, M.; Abramson, M.J.; Fairfax, B.P.; Knight, J.C.; Gupta, R.; Thompson, P.J.; Holt, P.; Sly, P.; Hirschhorn, J.N.; Blekic, M.; Weidinger, S.; Hakonarsson, H.; Stefansson, K.; Heinrich, J.; Postma, D.S.; Custovic, A.; Pennell, C.E.; Jarvelin, M.-R.; Koppelman, G.H.; Timpson, N.; Ferreira, M.A.; Bisgaard, H.; Henderson, A.J. url  doi
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  Title Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization Type
  Year (down) 2013 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 45 Issue 8 Pages 902-906  
  Keywords Alleles; Computational Biology; Gene Regulatory Networks; *Genetic Loci; *Genome-Wide Association Study; Genomics; Humans; Hypersensitivity/*genetics/metabolism; Phenotype; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Signal Transduction  
  Abstract Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.  
  Address COPSAC (Copenhagen Prospective Studies on Asthma in Childhood), Health Sciences, University of Copenhagen & Copenhagen University Hospital, Gentofte, Denmark. kb@copsac.com  
  Corporate Author EArly Genetics and Lifecourse Epidemiology (EAGLE) Consortium Thesis  
  Impact Factor 29,352 First Author Bonnelykke, K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Henderson, A.J.  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23817571 Approved no  
  Call Number Serial 97  
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