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Author Bonnelykke, K.; Chawes, B.L.K.; Vindfeld, S.; Moore, A.C.; Bisgaard, H. url  doi
  Title Aerosol particle size does not predict pharmacokinetic determined lung dose in children Type Journal Article
  Year (down) 2013 Publication Journal of Clinical Pharmacology Abbreviated Journal J Clin Pharmacol  
  Volume 53 Issue 5 Pages 517-522  
  Keywords Administration, Inhalation; Adolescent; Aerosols; Androstadienes/administration & dosage/blood/*pharmacokinetics; Anti-Asthmatic Agents/administration & dosage/blood/*pharmacokinetics; Area Under Curve; Asthma/*metabolism; Child; Child, Preschool; Female; Fluticasone; Humans; Lung/*metabolism; Male; Nebulizers and Vaporizers; Particle Size  
  Abstract In vitro measures of aerosol particles size, such as the fine particle mass, play a pivotal role for approval of inhaled anti-asthmatic drugs. However, the validity as a measure of dose to the lungs in children lacks evidence. In this study we investigated for the first time the association between an in vivo estimate of lung dose of inhaled drug in children and the corresponding particle size segments assessed ex vivo. Lung dose of fluticasone propionate after inhalation from a dry powder inhaler (Diskus(R)) was studied in 23 children aged 4-7 and 12-15 years with mild asthma. Six-hour pharmacokinetics was assessed after single inhalation. The corresponding emitted mass of drug in segments of aerosol particle size was assessed ex vivo by replicating the inhalation flows recorded by transducers built into the Diskus(R) inhaler and re-playing them in a breathing simulator. There was no correlation between any inhaled particle size segment and lung dose assessed by pharmacokinetics and adjusted for age and body size. Measures of particles size segments were not related to lung dose in children. Until further evidence is provided it may be warranted to emphasize pharmacokinetic or pharmacodynamic assessments of drug delivery to the lung.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Danish Pediatric Asthma Center, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 02,475 First Author Bonnelykke, K. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0091-2700 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23553595 Approved no  
  Call Number Serial 94  
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