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Author Stensballe, L.G.; Simonsen, J.; Jensen, S.M.; Bonnelykke, K.; Bisgaard, H. url  doi
  Title Use of antibiotics during pregnancy increases the risk of asthma in early childhood Type Journal Article
  Year (down) 2013 Publication The Journal of Pediatrics Abbreviated Journal J Pediatr  
  Volume 162 Issue 4 Pages 832-838.e3  
  Keywords Adrenal Cortex Hormones/therapeutic use; Algorithms; Anti-Bacterial Agents/*adverse effects; Asthma/*etiology; Child, Preschool; Cohort Studies; Denmark; Eczema/etiology; Female; Hospitalization; Humans; Male; Pregnancy; Pregnancy Complications, Infectious/drug therapy; Prenatal Exposure Delayed Effects; Risk; Treatment Outcome  
  Abstract OBJECTIVES: To investigate the hypothesis that mother's use of antibiotics in pregnancy could influence asthma and eczema in early life. STUDY DESIGN: Subjects were included from the Copenhagen Prospective Study on Asthma in Childhood cohort of children born of mothers with asthma (N = 411). Severe asthma exacerbations and eczema were diagnosed by research unit physicians. Replication was sought in children from the Danish National Birth Cohort (N = 30 675). Asthma outcomes were hospitalization and use of inhaled corticosteroids. Eczema was defined by an algorithm developed from cases of clinically verified eczema. All children were followed to age 5 years in a cohort study design. RESULTS: The Copenhagen Prospective Study on Asthma in Childhood data showed increased risk of asthma exacerbation (hazard ratio 1.98 [95% CI 1.08-3.63]) if mothers had used antibiotics during third trimester. The Danish National Birth Cohort confirmed increased risk of asthma hospitalization (hazard ratio 1.17 [1.00-1.36]), and inhaled corticosteroids (1.18 [1.10-1.27]) in the children if mothers used antibiotics any time during pregnancy. In the subgroup of mothers using antibiotics for nonrespiratory infection, the children also had increased risk of asthma. CONCLUSION: We found increased risk of asthma associated with maternal antibiotic use in a clinical study of a birth cohort with increased risk of asthma and replicated this finding in an unselected national birth cohort, and in a subgroup using antibiotics for nonrespiratory infections. This supports a role for bacterial ecology in pre- or perinatal life for the development of asthma.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, and The Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Copenhagen, Denmark.  
  Corporate Author Thesis  
  Impact Factor 03,790 First Author Stensballe, L.G. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0022-3476 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23140881 Approved no  
  Call Number Serial 90  
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