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Author Folsgaard, N.V.; Schjorring, S.; Chawes, B.L.; Rasmussen, M.A.; Krogfelt, K.A.; Brix, S.; Bisgaard, H. url  doi
  Title Pathogenic bacteria colonizing the airways in asymptomatic neonates stimulates topical inflammatory mediator release Type Journal Article
  Year (down) 2013 Publication American Journal of Respiratory and Critical Care Medicine Abbreviated Journal Am J Respir Crit Care Med  
  Volume 187 Issue 6 Pages 589-595  
  Keywords Asthma/*immunology/*microbiology; Bronchi/*immunology/*microbiology; Colony Count, Microbial; Haemophilus influenzae/isolation & purification; Humans; Hypopharynx/microbiology; Infant, Newborn; Inflammation Mediators/*metabolism; Moraxella (Branhamella) catarrhalis/isolation & purification; Mucous Membrane/immunology; Streptococcus pneumoniae/isolation & purification; T-Lymphocytes/immunology  
  Abstract RATIONALE: Bacterial colonization of neonatal airways with the pathogenic bacterial species, Moraxella catarrhalis, Streptococcus pneumoniae, and Haemophilus influenzae, is associated with later development of childhood asthma. OBJECTIVES: To study a possible association between colonization with pathogenic bacterial strains and the immune signature of the upper airways in healthy neonates. METHODS: A total of 20 cytokines and chemokines were quantified in vivo in the airway mucosal lining fluid of 662 neonates from the Copenhagen Prospective Study of Asthma in Childhood 2010 birth cohort. Colonization of the hypopharynx with M. catarrhalis, S. pneumoniae, H. influenzae, and Staphylococcus aureus was assessed simultaneously. The association between immune signatures and bacterial colonization or noncolonized controls was analyzed using conventional statistical methods supplemented by a multivariate approach for pattern identification. MEASUREMENTS AND MAIN RESULTS: Colonization with M. catarrhalis and H. influenzae induced a mixed T helper cell (Th) type 1/Th2/Th17 response with high levels of IL-1beta (M. catarrhalis, P = 2.2 x 10(-12); H. influenzae, P = 7.1 x 10(-10)), TNF-alpha (M. catarrhalis, P = 1.5 x 10(-9); H. influenzae, P = 5.9 x 10(-7)), and macrophage inflammatory protein-1beta (M. catarrhalis, P = 1.6 x 10(-11); H. influenzae, P = 2.7 x 10(-7)). S. aureus colonization demonstrated a Th17-promoting profile with elevated IL-17 levels (P = 1.6 x 10(-24)). S. pneumoniae colonization was not significantly associated with any of the mediators. CONCLUSIONS: M. catarrhalis and H. influenzae colonization of the airways of asymptomatic neonates is associated with an inflammatory immune response of the airway mucosa, which may result in chronic inflammation.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte, Ledreborg Alle 34, Gentofte, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 12,996 First Author Folsgaard, N.V. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1073-449X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23370914 Approved no  
  Call Number Serial 89  
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