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Author Horikoshi, M.; Yaghootkar, H.; Mook-Kanamori, D.O.; Sovio, U.; Taal, H.R.; Hennig, B.J.; Bradfield, J.P.; St Pourcain, B.; Evans, D.M.; Charoen, P.; Kaakinen, M.; Cousminer, D.L.; Lehtimaki, T.; Kreiner-Moller, E.; Warrington, N.M.; Bustamante, M.; Feenstra, B.; Berry, D.J.; Thiering, E.; Pfab, T.; Barton, S.J.; Shields, B.M.; Kerkhof, M.; van Leeuwen, E.M.; Fulford, A.J.; Kutalik, Z.; Zhao, J.H.; den Hoed, M.; Mahajan, A.; Lindi, V.; Goh, L.-K.; Hottenga, J.-J.; Wu, Y.; Raitakari, O.T.; Harder, M.N.; Meirhaeghe, A.; Ntalla, I.; Salem, R.M.; Jameson, K.A.; Zhou, K.; Monies, D.M.; Lagou, V.; Kirin, M.; Heikkinen, J.; Adair, L.S.; Alkuraya, F.S.; Al-Odaib, A.; Amouyel, P.; Andersson, E.A.; Bennett, A.J.; Blakemore, A.I.F.; Buxton, J.L.; Dallongeville, J.; Das, S.; de Geus, E.J.C.; Estivill, X.; Flexeder, C.; Froguel, P.; Geller, F.; Godfrey, K.M.; Gottrand, F.; Groves, C.J.; Hansen, T.; Hirschhorn, J.N.; Hofman, A.; Hollegaard, M.V.; Hougaard, D.M.; Hypponen, E.; Inskip, H.M.; Isaacs, A.; Jorgensen, T.; Kanaka-Gantenbein, C.; Kemp, J.P.; Kiess, W.; Kilpelainen, T.O.; Klopp, N.; Knight, B.A.; Kuzawa, C.W.; McMahon, G.; Newnham, J.P.; Niinikoski, H.; Oostra, B.A.; Pedersen, L.; Postma, D.S.; Ring, S.M.; Rivadeneira, F.; Robertson, N.R.; Sebert, S.; Simell, O.; Slowinski, T.; Tiesler, C.M.T.; Tonjes, A.; Vaag, A.; Viikari, J.S.; Vink, J.M.; Vissing, N.H.; Wareham, N.J.; Willemsen, G.; Witte, D.R.; Zhang, H.; Zhao, J.; Wilson, J.F.; Stumvoll, M.; Prentice, A.M.; Meyer, B.F.; Pearson, E.R.; Boreham, C.A.G.; Cooper, C.; Gillman, M.W.; Dedoussis, G.V.; Moreno, L.A.; Pedersen, O.; Saarinen, M.; Mohlke, K.L.; Boomsma, D.I.; Saw, S.-M.; Lakka, T.A.; Korner, A.; Loos, R.J.F.; Ong, K.K.; Vollenweider, P.; van Duijn, C.M.; Koppelman, G.H.; Hattersley, A.T.; Holloway, J.W.; Hocher, B.; Heinrich, J.; Power, C.; Melbye, M.; Guxens, M.; Pennell, C.E.; Bonnelykke, K.; Bisgaard, H.; Eriksson, J.G.; Widen, E.; Hakonarson, H.; Uitterlinden, A.G.; Pouta, A.; Lawlor, D.A.; Smith, G.D.; Frayling, T.M.; McCarthy, M.I.; Grant, S.F.A.; Jaddoe, V.W.V.; Jarvelin, M.-R.; Timpson, N.J.; Prokopenko, I.; Freathy, R.M. url  doi
  Title New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism Type Journal Article
  Year (down) 2013 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 45 Issue 1 Pages 76-82  
  Keywords Adult; Birth Weight/*genetics; Blood Pressure/genetics; Body Height/*genetics; Diabetes Mellitus, Type 2/genetics; Female; Fetal Development/*genetics; *Genetic Linkage; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Infant, Newborn; Male; Meta-Analysis as Topic; Polymorphism, Single Nucleotide; *Quantitative Trait Loci  
  Abstract Birth weight within the normal range is associated with a variety of adult-onset diseases, but the mechanisms behind these associations are poorly understood. Previous genome-wide association studies of birth weight identified a variant in the ADCY5 gene associated both with birth weight and type 2 diabetes and a second variant, near CCNL1, with no obvious link to adult traits. In an expanded genome-wide association meta-analysis and follow-up study of birth weight (of up to 69,308 individuals of European descent from 43 studies), we have now extended the number of loci associated at genome-wide significance to 7, accounting for a similar proportion of variance as maternal smoking. Five of the loci are known to be associated with other phenotypes: ADCY5 and CDKAL1 with type 2 diabetes, ADRB1 with adult blood pressure and HMGA2 and LCORL with adult height. Our findings highlight genetic links between fetal growth and postnatal growth and metabolism.  
  Address Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK  
  Corporate Author Early Growth Genetics (EGG) Consortium Thesis  
  Impact Factor 29,352 First Author Horikoshi, M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Freathy, R.M.  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23202124; PMCID:PMC3605762 Approved no  
  Call Number Serial 88  
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