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Author Malby Schoos, A.-M.; Chawes, B.L.K.; Bonnelykke, K.; Bisgaard, H. url  doi
  Title Fraction of exhaled nitric oxide and bronchial responsiveness are associated and continuous traits in young children independent of asthma Type Journal Article
  Year (down) 2012 Publication Chest Abbreviated Journal Chest  
  Volume 142 Issue 6 Pages 1562-1568  
  Keywords Air; Asthma/*metabolism/*physiopathology; Biomarkers/metabolism; Bronchi/*metabolism/*physiopathology; Child; Cohort Studies; Cold Temperature; Denmark; Exhalation; Female; Humans; Hyperventilation/metabolism/physiopathology; Linear Models; Male; Nitric Oxide/*metabolism; Severity of Illness Index  
  Abstract BACKGROUND: Elevated fraction of exhaled nitric oxide (FENO) and bronchial hyperresponsiveness are used as surrogate markers of asthma. These traits may be continuous in the population. The objective of this study was to investigate whether FENO and bronchial responsiveness are associated in both children with and children without a history of asthma symptoms. METHODS: One hundred ninety-six 6-year-old children with no asthma symptoms, intermittent asthma symptoms, and persistent asthma were randomly included from the Copenhagen Prospective Study on Asthma in Childhood prospective clinical birth cohort of mothers with asthma. Bronchial responsiveness was assessed as the relative change in specific airway resistance after cold dry air hyperventilation. FENO measurements were performed prior to the hyperventilation test. The association between FENO and bronchial responsiveness was assessed by generalized linear models. RESULTS: Bronchial responsiveness and FENO exhibited a significant and linear association in the population. A doubling of FENO corresponded to an 8.4% (95% CI, 3.7%-13.1%; P = .0006) increase in airway resistance after challenge testing and remained significant after adjustment for sex, allergic rhinitis, current asthma, inhaled corticosteroid treatment, and upper respiratory tract infections prior to testing. Stratified analyses showed similar associations in children with and without asthma. CONCLUSIONS: FENO and bronchial responsiveness are associated and continuous traits in young children regardless of asthma symptoms, suggesting a continuous subclinical to clinical process underlying asthma. The findings also suggest caution against the use of these surrogate markers for a dichotomized approach to asthma diagnosis.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, and Copenhagen University Hospital Gentofte, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 07,483 First Author Malby Schoos, A.-M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0012-3692 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23187857 Approved no  
  Call Number Serial 86  
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