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Author Kreiner-Moller, E.; Chawes, B.L.K.; Caye-Thomasen, P.; Bonnelykke, K.; Bisgaard, H. url  doi
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  Title Allergic rhinitis is associated with otitis media with effusion: a birth cohort study Type Journal Article
  Year (down) 2012 Publication Clinical and Experimental Allergy Abbreviated Journal Clin Exp Allergy  
  Volume 42 Issue 11 Pages 1615-1620  
  Keywords Asthma/complications; Child; Child, Preschool; Cohort Studies; Denmark; Eczema/complications; Humans; Infant; Infant, Newborn; Morbidity; Otitis Media with Effusion/*complications; Prospective Studies; Rhinitis, Allergic; Rhinitis, Allergic, Perennial/*complications  
  Abstract BACKGROUND: Childhood otitis media with effusion is a common disease and a link to allergic diseases has been suggested. OBJECTIVE: To investigate the association between atopic disease and otitis media with effusion diagnosed according to strict objective case definitions by age 6 years. METHODS: We evaluated 291 children in the 6th year of life from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC) 2000 birth cohort. Otitis media with effusion was diagnosed based on tympanometric and objective evaluation. Asthma, eczema, allergic- and non-allergic rhinitis was diagnosed prospectively by pre-defined algorithms. Nasal mucosal swelling was assessed using acoustic rhinometry and nasal eosinophilia from scrapings. Analyses were performed using logistic regression and adjusted for dog, cat and smoking exposure, paternal atopy, household income, older siblings, gender and number of acute otitis media episodes. RESULTS: Otitis media with effusion was diagnosed in 39% of the cohort and was associated with allergic rhinitis (aOR = 3.36, CI = 1.26-8.96, P = 0.02), but not with nasal mucosal swelling, nasal oeosinophilia, non-allergic rhinitis, asthma or eczema. CONCLUSION: Otitis media with effusion is closely associated with allergic rhinitis presumably caused by allergic inflammation, but not mechanical nasal mucosal swelling. These findings warrant an increased awareness of otitis media with effusion in children with allergic rhinitis.  
  Address COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 04,769 First Author Kreiner-Moller, E. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0954-7894 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23106661 Approved no  
  Call Number Serial 84  
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