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Author Folsgaard, N.V.; Chawes, B.L.K.; Bonnelykke, K.; Jenmalm, M.C.; Bisgaard, H. url  doi
  Title Cord blood Th2-related chemokine CCL22 levels associate with elevated total-IgE during preschool age Type Journal Article
  Year (down) 2012 Publication Clinical and Experimental Allergy Abbreviated Journal Clin Exp Allergy  
  Volume 42 Issue 11 Pages 1596-1603  
  Keywords Antibody Specificity/immunology; Asthma/blood/immunology; Biomarkers/blood; Chemokine CCL22/*blood; Child; Child, Preschool; Dermatitis, Atopic/blood/immunology; Eosinophils; Female; Fetal Blood/*immunology; Humans; Immunoglobulin E/*blood; Infant; Leukocyte Count; Male; Rhinitis, Allergic; Rhinitis, Allergic, Perennial/blood/immunology; Th2 Cells/*immunology/metabolism  
  Abstract BACKGROUND: Early-life immune deviation is suspected in the inception of atopic disease. OBJECTIVE: To investigate the association between cord blood chemokines and the subsequent development of atopic biomarkers and clinical end-points during the first 6 years of life. METHODS: The Th1-associated chemokines CXCL10 and CXCL11 and the Th2-associated chemokines CCL17 and CCL22 were assessed in cord blood of asymptomatic at-risk newborn children from the Copenhagen Prospective Study on Asthma in Childhood (COPSAC(2000) ) birth cohort and associated with the longitudinal development of biomarkers and clinical end-points of asthma, eczema, and allergic rhinitis during the first 6 years of life. RESULTS: Cord blood CCL22 levels were significantly associated to total-IgE levels measured at four time-points during the first 6 years of life; overall odds ratio, 1.54 [CI, 1.25-1.89; P < 0.0001]. CXCL10 and CXCL11 were not associated with development of any atopic disorders or biomarkers. CONCLUSION AND CLINICAL RELEVANCE: High cord blood levels of the Th2 related chemokine CCL22 were significantly associated with high total- IgE levels during the first 6 years of life, but not with specific sensitization, asthma, eczema or allergic rhinitis. This suggests an inborn skewing of the immune system in healthy newborns developing elevated total- IgE later in life.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Copenhagen University Hospital, Gentofte, Denmark  
  Corporate Author Thesis  
  Impact Factor 04,769 First Author Folsgaard, N.V. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0954-7894 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23106659 Approved no  
  Call Number Serial 83  
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