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Author Taal, H.R.; St Pourcain, B.; Thiering, E.; Das, S.; Mook-Kanamori, D.O.; Warrington, N.M.; Kaakinen, M.; Kreiner-Moller, E.; Bradfield, J.P.; Freathy, R.M.; Geller, F.; Guxens, M.; Cousminer, D.L.; Kerkhof, M.; Timpson, N.J.; Ikram, M.A.; Beilin, L.J.; Bonnelykke, K.; Buxton, J.L.; Charoen, P.; Chawes, B.L.K.; Eriksson, J.; Evans, D.M.; Hofman, A.; Kemp, J.P.; Kim, C.E.; Klopp, N.; Lahti, J.; Lye, S.J.; McMahon, G.; Mentch, F.D.; Muller-Nurasyid, M.; O'Reilly, P.F.; Prokopenko, I.; Rivadeneira, F.; Steegers, E.A.P.; Sunyer, J.; Tiesler, C.; Yaghootkar, H.; Breteler, M.M.B.; Decarli, C.; Breteler, M.M.B.; Debette, S.; Fornage, M.; Gudnason, V.; Launer, L.J.; van der Lugt, A.; Mosley, T.H.J.; Seshadri, S.; Smith, A.V.; Vernooij, M.W.; Blakemore, A.I.F.; Chiavacci, R.M.; Feenstra, B.; Fernandez-Banet, J.; Grant, S.F.A.; Hartikainen, A.-L.; van der Heijden, A.J.; Iniguez, C.; Lathrop, M.; McArdle, W.L.; Molgaard, A.; Newnham, J.P.; Palmer, L.J.; Palotie, A.; Pouta, A.; Ring, S.M.; Sovio, U.; Standl, M.; Uitterlinden, A.G.; Wichmann, H.-E.; Vissing, N.H.; DeCarli, C.; van Duijn, C.M.; McCarthy, M.I.; Koppelman, G.H.; Estivill, X.; Hattersley, A.T.; Melbye, M.; Bisgaard, H.; Pennell, C.E.; Widen, E.; Hakonarson, H.; Smith, G.D.; Heinrich, J.; Jarvelin, M.-R.; Jaddoe, V.W.V. url  doi
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  Title Common variants at 12q15 and 12q24 are associated with infant head circumference Type Journal Article
  Year (down) 2012 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 44 Issue 5 Pages 532-538  
  Keywords Chromosomes, Human, Pair 12/*genetics; European Continental Ancestry Group/*genetics; Female; Genetic Loci; Genetic Markers; Genome-Wide Association Study; Head/*growth & development/*pathology; Humans; Infant; Male; Meta-Analysis as Topic; Polymorphism, Single Nucleotide/*genetics; Pregnancy; Pregnancy Complications/*etiology/*pathology  
  Abstract To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy and/or birth cohorts) and followed up three lead signals in six replication studies (combined N = 19,089). rs7980687 on chromosome 12q24 (P = 8.1 x 10(-9)) and rs1042725 on chromosome 12q15 (P = 2.8 x 10(-10)) were robustly associated with head circumference in infancy. Although these loci have previously been associated with adult height, their effects on infant head circumference were largely independent of height (P = 3.8 x 10(-7) for rs7980687 and P = 1.3 x 10(-7) for rs1042725 after adjustment for infant height). A third signal, rs11655470 on chromosome 17q21, showed suggestive evidence of association with head circumference (P = 3.9 x 10(-6)). SNPs correlated to the 17q21 signal have shown genome-wide association with adult intracranial volume, Parkinson's disease and other neurodegenerative diseases, indicating that a common genetic variant in this region might link early brain growth with neurological disease in later life.  
  Address Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands  
  Corporate Author Early Growth Genetics Consortium Thesis  
  Impact Factor 29,352 First Author Taal, H.R. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Jaddoe, V.W.V.  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22504419; PMCID:PMC3773913 Approved no  
  Call Number Serial 74  
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