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Author Folsgaard, N.V.; Chawes, B.L.; Rasmussen, M.A.; Bischoff, A.L.; Carson, C.G.; Stokholm, J.; Pedersen, L.; Hansel, T.T.; Bonnelykke, K.; Brix, S.; Bisgaard, H. url  doi
  Title Neonatal cytokine profile in the airway mucosal lining fluid is skewed by maternal atopy Type Journal Article
  Year (down) 2012 Publication American Journal of Respiratory and Critical Care Medicine Abbreviated Journal Am J Respir Crit Care Med  
  Volume 185 Issue 3 Pages 275-280  
  Keywords Chemokines/genetics/metabolism; Cytokines/*genetics/metabolism; Down-Regulation; Female; *Genomic Imprinting; Humans; Hypersensitivity, Immediate/*genetics/metabolism; Infant, Newborn; Male; Mothers; Nasal Mucosa/*metabolism; Principal Component Analysis; Prospective Studies  
  Abstract RATIONALE: Heredity from mother or father may impact differently in complex diseases, such as atopy. Maternal atopy is a stronger risk factor than paternal atopy for the development of atopy in the offspring. We hypothesized that mother's and father's atopy would have a differential imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. OBJECTIVES: To study parental atopic imprinting on the cytokines and chemokines in the upper airway mucosal lining fluid of healthy neonates. METHODS: Eighteen cytokines and chemokines were quantified in nasal mucosal lining fluid in 309 neonates from the novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC) birth cohort. MEASUREMENTS AND MAIN RESULTS: Maternal, but not paternal, atopic status (asthma, hay fever, or eczema with or without sensitization) was associated with general down-regulation of all 18 mediators assessed by principal component analysis (overall P = 0.015). CONCLUSIONS: Maternal atopy, but not paternal atopy, showed a strong linkage with a suppressed mucosal cytokine and chemokine signature in asymptomatic neonates, suggesting imprinting by the maternal milieu in utero or perinatal life.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Gentofte, Denmark  
  Corporate Author Thesis  
  Impact Factor 12,996 First Author Folsgaard, N.V. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1073-449X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:22077068 Approved no  
  Call Number Serial 71  
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