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Author Stokholm, J.; Schjorring, S.; Pedersen, L.; Bischoff, A.L.; Folsgaard, N.; Carson, C.G.; Chawes, B.; Bonnelykke, K.; Molgaard, A.; Krogfelt, K.A.; Bisgaard, H. url  doi
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  Title Living with cat and dog increases vaginal colonization with E. coli in pregnant women Type Journal Article
  Year (down) 2012 Publication PloS one Abbreviated Journal PLoS One  
  Volume 7 Issue 9 Pages e46226  
  Keywords Animals; Anti-Bacterial Agents/therapeutic use; Cats; Dogs; Escherichia coli/*pathogenicity; Female; Humans; Odds Ratio; Pregnancy; Risk Factors; Urinary Tract Infections/drug therapy/epidemiology/microbiology; Vagina/*microbiology  
  Abstract BACKGROUND: Furred pets in the household are known reservoirs for pathogenic bacteria, but it is not known if transmission of bacteria between pet and owner leads to significantly increased rate of infections. We studied whether cats and dogs living in the household of pregnant women affect the commensal vaginal flora, and furthermore the need for oral antibiotics and rate of urinary tract infections during pregnancy. METHODS: The novel unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC(2010)) pregnancy cohort of 709 women participated in this analysis. Detailed information on pet exposure, oral antibiotic prescriptions filled at pharmacy and urinary tract infection during pregnancy was obtained and verified prospectively during clinic visits. Vaginal cultures were obtained at pregnancy week 36. RESULTS: Women, who had cat or dog in the home during pregnancy, had a different vaginal flora, in particular with increased Escherichia coli (E. coli) colonization; odds ratio after adjustment for lifestyle confounders and antibiotics 2.20, 95% CI, [1.27-3.80], p=0.005. 43% of women living with cat and/or dog in the home used oral antibiotics compared to 33% of women with no cat or dog; adjusted odds ratio 1.51, 95% CI, [1.08-2.12], p=0.016. Women living with cat had increased frequency of self-reported urinary tract infection; adjusted odds ratio 1.57, 95% CI, [1.02-2.43], p=0.042. CONCLUSIONS: The increased vaginal E. coli colonization in women living with cat or dog suggests a clinically important transmission of pathogenic bacteria from pet to owner substantiated by increased rate of antibiotic use and urinary tract infections which, which is of particular concern during pregnancy.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Naestved Hospital, Naestved, Denmark  
  Corporate Author Thesis  
  Impact Factor 03,234 First Author Stokholm, J. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:23049986; PMCID:PMC3458003 Approved no  
  Call Number Serial 68  
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