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Author Bisgaard, H.; Hermansen, M.N.; Bonnelykke, K.; Stokholm, J.; Baty, F.; Skytt, N.L.; Aniscenko, J.; Kebadze, T.; Johnston, S.L. url  openurl
  Title Association of bacteria and viruses with wheezy episodes in young children: prospective birth cohort study Type Journal Article
  Year (down) 2010 Publication BMJ Abbreviated Journal BMJ  
  Volume 341 Issue Pages c4978  
  Keywords Acute Disease; Bacteria/isolation & purification; Bacterial Infections/*microbiology; Bronchi/microbiology; Bronchial Diseases/*microbiology; Child, Preschool; Humans; Infant; Prospective Studies; Respiratory Sounds/*etiology; Respiratory Tract Infections/*microbiology; Virus Diseases/virology; Viruses/isolation & purification  
  Abstract OBJECTIVE: To study the association between wheezy symptoms in young children and the presence of bacteria in the airways. DESIGN: Birth cohort study. SETTING: Clinical research unit in Copenhagen. PARTICIPANTS: Children of asthmatic mothers, from age 4 weeks to 3 years, with planned visits and acute admissions to the research clinic. MAIN OUTCOME MEASURE: Frequency of bacteria and virus carriage in airway aspirates during wheezy episodes and at planned visits without respiratory symptoms. RESULTS: 984 samples (361 children) were analysed for bacteria, 844 (299 children) for viruses, and 696 (277 children) for both viruses and bacteria. Wheezy episodes were associated with both bacterial infection (odds ratio 2.9, 95% confidence interval 1.9 to 4.3; P<0.001) and virus infection (2.8, 1.7 to 4.4; P<0.001). The associations of bacteria and viruses were independent of each other. CONCLUSION: Acute wheezy episodes in young children were significantly associated with bacterial infections similar to but independent of the association with virus infections.  
  Address The Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, and The Danish Pediatric Asthma Centre, Copenhagen University Hospital, Gentofte, Ledreborg Alle 34, DK-2820 Gentofte, Copenhagen, Denmark. Bisgaard@copsac.com  
  Corporate Author Thesis  
  Impact Factor 17,445 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Johnston, S.L.  
  ISSN 0959-535X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:20921080; PMCID:PMC2950260 Approved no  
  Call Number Serial 60  
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