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Author Schoos, A.-M.M.; Chawes, B.L.K.; Folsgaard, N.V.; Samandari, N.; Bonnelykke, K.; Bisgaard, H. url  doi
  Title Disagreement between skin prick test and specific IgE in young children Type Journal Article
  Year (down) 2015 Publication Allergy Abbreviated Journal Allergy  
  Volume 70 Issue 1 Pages 41-48  
  Keywords Allergens/immunology; Antibody Specificity/*immunology; Child; Child, Preschool; Female; Food Hypersensitivity/diagnosis/immunology; Humans; Hypersensitivity/*diagnosis/epidemiology/*immunology; Immunoglobulin E/blood/*immunology; Infant; Male; Prevalence; ROC Curve; Reproducibility of Results; Rhinitis, Allergic/diagnosis/immunology; Risk Factors; Skin Tests/*standards; Time Factors; agreement; children; sensitization; skin prick test; specific IgE  
  Abstract BACKGROUND: Skin prick test (SPT) and measurement of serum-specific IgE (sIgE) level are important tools for the clinician to diagnose allergic sensitization. However, little is known about the agreement between the two methods in young children. METHODS: SPT and sIgE levels were assessed simultaneously for 16 common inhalant and food allergens at age (1/2), 1(1/2), 4, and 6 years in 389 children from the Copenhagen Prospective Study on Asthma in Childhood2000 (COPSAC2000 ) at-risk birth cohort. Agreement between the two methods for diagnosing inhalant and food allergic sensitization at the four age points was analyzed using kappa statistics. RESULTS: The prevalence of inhalant allergen sensitization increased during childhood diagnosed by both sIgE levels (0.6% to 4.2% to 18.1% to 24.8%, P < 0.0001) and SPT results (1.5% to 3.8% to 8.4% to 15.4%, P < 0.0001). In contrast, the prevalence of food sensitization increased during childhood when diagnosed from sIgE (7.8% to 12.1% to 15.0% to 18.9%, P < 0.0001), but decreased when diagnosed from SPT (5.3% to 5.1% to 3.7% to 3.0%, P = 0.05). Overall, the agreement between SPT and sIgE levels was poor to moderate (all kappa-coefficients </= 0.60) and decreased from moderate to slight for food allergens by increasing age (kappa-coefficients: 0.46 to 0.31 to 0.16 to 0.14). CONCLUSION: There is a substantial disagreement between SPT and sIgE for diagnosing allergic sensitization in young children, which increases with age for food sensitization. Choice of assessment method therefore has major impact on results with wide implications for both clinical practice and research.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health and Medical Sciences, University of Copenhagen & Danish Pediatric Asthma Center, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 06,028 First Author Schoos, A.-M.M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25224528 Approved no  
  Call Number Serial 56  
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