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Author Kreiner-Moller, E.; Strachan, D.P.; Linneberg, A.; Husemoen, L.L.N.; Bisgaard, H.; Bonnelykke, K. url  doi
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  Title 17q21 gene variation is not associated with asthma in adulthood Type Journal Article
  Year (down) 2015 Publication Allergy Abbreviated Journal Allergy  
  Volume 70 Issue 1 Pages 107-114  
  Keywords Adolescent; Adult; Age Factors; Aged; Alleles; Asthma/epidemiology/*genetics; *Chromosomes, Human, Pair 17; Cross-Sectional Studies; Female; Gene Frequency; Genetic Association Studies; Genetic Predisposition to Disease; *Genetic Variation; Genotype; Humans; Male; Middle Aged; Odds Ratio; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Respiratory Function Tests; Risk Factors; Sex Factors; Young Adult; adults; asthma; genetic association studies; respiratory function tests  
  Abstract BACKGROUND: 17q21 gene variants are the strongest known genetic determinants for childhood asthma and have been reported to interact with environmental tobacco smoke exposure in childhood. It remains unclear whether individuals with 17q21 risk variants have increased risk of asthma or reduced lung function in adulthood. The aim was to examine the association between the 17q21 region and current adult asthma and lung function, and interaction with active smoking. METHODS: We investigated the single nucleotide polymorphism rs7216389 at the 17q21 locus in 3471 adults from the Health2006 cross-sectional study and in 7008 adults from The British 1958 Birth Cohort and examined the association with current asthma, spirometry measures, and related atopic traits. Analyses were performed for interaction with active smoking. RESULTS: We found no association between rs7216389[T] and asthma when meta-analyzed (OR = 1.02 [0.92-1.13], P = 0.81). The risk variant was associated with reduced FEV1 as compared to normal FEV1 (OR = 1.10 [1.01-1.12], P = 0.033) and with allergic sensitization (OR = 1.10 [1.03-1.17], P = 0.003). Individuals with rs7216389 risk variants smoked as frequently as individuals without risk variants, and there was no evidence that smoking modified the association between rs7216389 and asthma. CONCLUSION: Our study suggests that the 17q21 rs7216389 locus variant does not substantially influence asthma risk in adulthood or susceptibility to detrimental effects of active smoking. This contrasts the findings in children and suggests that this locus is associated with a childhood-specific asthma endotype.  
  Address COPSAC, The Copenhagen Prospective Studies on Asthma in Childhood, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark; The Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark  
  Corporate Author Thesis  
  Impact Factor 06,028 First Author Kreiner-Moller, E. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bonnelykke, K.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25331618 Approved no  
  Call Number Serial 55  
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