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Author Bischoff, A.L.; Folsgaard, N.V.; Vissing, N.H.; Birch, S.; Brix, S.; Bisgaard, H. url  doi
  Title Airway mucosal immune-suppression in neonates of mothers receiving A(H1N1)pnd09 vaccination during pregnancy Type Journal Article
  Year (down) 2015 Publication The Pediatric Infectious Disease Journal Abbreviated Journal Pediatr Infect Dis J  
  Volume 34 Issue 1 Pages 84-90  
  Keywords Cohort Studies; Cytokines/analysis; Female; Humans; *Immune Tolerance; Infant, Newborn; Influenza A Virus, H1N1 Subtype/*immunology; Influenza Vaccines/administration & dosage/*immunology; Mothers; Nasal Mucosa/immunology; Pregnancy; Prospective Studies; Respiratory System/*immunology; Respiratory Tract Infections/*epidemiology; Vaccination/*methods  
  Abstract BACKGROUND: It is recommended to vaccinate pregnant women against influenza. A possible impact on the immune expression of the fetus has never been studied. We aim to study the immune signature in the upper airways and the incidence of infections in neonates born to mothers receiving Influenza A(H1N1)pnd09 vaccination during pregnancy. METHODS: One hundred and fifty-six women from the unselected Copenhagen Prospective Study on Asthma in Childhood (COPSAC2010) received Influenza A(H1N1)pnd09-vaccination during the 2009 pandemic. Fifty-one mothers received the vaccine during pregnancy and 105 after pregnancy; 332 neonates of nonvaccinated mothers were included as secondary controls. Nasal mucosal lining fluid was sampled in 488 neonates and assessed for interleukin (IL)-12p70, IP-10, interferon-gamma (IFN)-gamma, tumor necrosis factor-alpha (TNF)-alpha, MIP-1beta, MCP-1, MCP-4, IL-4, IL-5, IL-13, eotaxin-1, eotaxin-3, TARC, MDC, IL-17, IL-1beta, IL-8, transforming growth factor beta (TGF)-beta1, IL-10 and IL-2. Infections were monitored the first year of life by daily diary cards and clinical controls. RESULTS: Neonates of mothers vaccinated during pregnancy had significant up-regulation of TGF-beta1 [ratio = 1.52 (1.22-1.90), P = 0.0002], and corresponding down-regulation (P < 0.05) of IL-12p70, IFN-gamma, IL-5, eotaxin-1, TARC, MDC, IL-8 in comparison to those vaccinated after pregnancy. The lag-time from vaccination during pregnancy to assessment of the immune signature showed significant and positive association to up-regulation of TGF-beta1 levels (P = 0.0003) and significant negative association to other mediators. The study was not powered to study differences in the incidence of infections in early infancy which did not differ between the study groups. CONCLUSION: Influenza A(H1N1)pnd09 vaccination during pregnancy up-regulates TGF-beta1 and down-regulates key mediators of the protective immunity.  
  Address *From the Copenhagen Prospective Studies on Asthma in Childhood: COPSAC, Health Sciences, University of Copenhagen, Copenhagen University Hospital, Copenhagen; and daggerCenter for Biological Sequence Analysis, Department of Systems Biology, Technical University of Denmark, Lyngby, Denmark  
  Corporate Author Thesis  
  Impact Factor 02,723 First Author Bischoff, A.L. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0891-3668 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:25229268 Approved no  
  Call Number Serial 53  
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