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Author Chawes, B.L.; Bonnelykke, K.; Jensen, P.F.; Schoos, A.-M.M.; Heickendorff, L.; Bisgaard, H. url  doi
  Title Cord blood 25(OH)-vitamin D deficiency and childhood asthma, allergy and eczema: the COPSAC2000 birth cohort study Type Journal Article
  Year (down) 2014 Publication PloS one Abbreviated Journal PLoS One  
  Volume 9 Issue 6 Pages e99856  
  Keywords Adult; Age of Onset; Asthma/blood/*epidemiology; Child; Child, Preschool; Cohort Studies; Denmark/epidemiology; Eczema/blood/*epidemiology; Female; *Fetal Blood/chemistry; Humans; Hypersensitivity/blood/*epidemiology; Infant; Infant, Newborn; Male; Pregnancy; Pregnancy Complications/blood/epidemiology; Vitamin D/*analogs & derivatives/analysis/blood; Vitamin D Deficiency/blood/*epidemiology; Young Adult  
  Abstract BACKGROUND: Epidemiological studies have suggested an association between maternal vitamin D dietary intake during pregnancy and risk of asthma and allergy in the offspring. However, prospective clinical studies on vitamin D measured in cord blood and development of clinical end-points are sparse. OBJECTIVE: To investigate the interdependence of cord blood 25-hydroxyvitamin D (25(OH)-Vitamin D) level and investigator-diagnosed asthma- and allergy-related conditions during preschool-age. METHODS: Cord blood 25(OH)-Vitamin D level was measured in 257 children from the Copenhagen Prospective Studies on Asthma in Childhood (COPSAC2000) at-risk mother-child cohort. Troublesome lung symptoms (TROLS), asthma, respiratory infections, allergic rhinitis, and eczema, at age 0-7 yrs were diagnosed exclusively by the COPSAC pediatricians strictly adhering to predefined algorithms. Objective assessments of lung function and sensitization were performed repeatedly from birth. RESULTS: After adjusting for season of birth, deficient cord blood 25(OH)-Vitamin D level (<50 nmol/L) was associated with a 2.7-fold increased risk of recurrent TROLS (HR = 2.65; 95% CI = 1.02-6.86), but showed no association with respiratory infections or asthma. We saw no association between cord blood 25(OH)-Vitamin D level and lung function, sensitization, rhinitis or eczema. The effects were unaffected from adjusting for multiple lifestyle factors. CONCLUSION: Cord blood 25(OH)-Vitamin D deficiency associated with increased risk of recurrent TROLS till age 7 years. Randomized controlled trials of vitamin D supplementation during pregnancy are needed to prove causality.  
  Address Copenhagen Prospective Studies on Asthma in Childhood, Health Sciences, University of Copenhagen, Danish Pediatric Asthma Center, Copenhagen University Hospital, Gentofte, Denmark  
  Corporate Author Thesis  
  Impact Factor 03,234 First Author Chawes, B.L. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24925304; PMCID:PMC4055727 Approved no  
  Call Number Serial 45  
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