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Author Sonnenschein-van der Voort, A.M.M.; Arends, L.R.; de Jongste, J.C.; Annesi-Maesano, I.; Arshad, S.H.; Barros, H.; Basterrechea, M.; Bisgaard, H.; Chatzi, L.; Corpeleijn, E.; Correia, S.; Craig, L.C.; Devereux, G.; Dogaru, C.; Dostal, M.; Duchen, K.; Eggesbo, M.; van der Ent, C.K.; Fantini, M.P.; Forastiere, F.; Frey, U.; Gehring, U.; Gori, D.; van der Gugten, A.C.; Hanke, W.; Henderson, A.J.; Heude, B.; Iniguez, C.; Inskip, H.M.; Keil, T.; Kelleher, C.C.; Kogevinas, M.; Kreiner-Moller, E.; Kuehni, C.E.; Kupers, L.K.; Lancz, K.; Larsen, P.S.; Lau, S.; Ludvigsson, J.; Mommers, M.; Nybo Andersen, A.-M.; Palkovicova, L.; Pike, K.C.; Pizzi, C.; Polanska, K.; Porta, D.; Richiardi, L.; Roberts, G.; Schmidt, A.; Sram, R.J.; Sunyer, J.; Thijs, C.; Torrent, M.; Viljoen, K.; Wijga, A.H.; Vrijheid, M.; Jaddoe, V.W.V.; Duijts, L. url  doi
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  Title [IF2015: 11,476] Preterm birth, infant weight gain, and childhood asthma risk: a meta-analysis of 147,000 European children Type Journal Article
  Year (down) 2014 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 133 Issue 5 Pages 1317-1329  
  Keywords *Asthma/epidemiology/pathology/physiopathology; *Birth Weight; Europe/epidemiology; Female; *Gestational Age; Humans; Infant; Infant, Newborn; Male; *Premature Birth/epidemiology/pathology/physiopathology; Risk Factors; *Weight Gain; Gestational age; asthma; children; cohort studies; epidemiology; infant growth; low birth weight; wheezing  
  Abstract BACKGROUND: Preterm birth, low birth weight, and infant catch-up growth seem associated with an increased risk of respiratory diseases in later life, but individual studies showed conflicting results. OBJECTIVES: We performed an individual participant data meta-analysis for 147,252 children of 31 birth cohort studies to determine the associations of birth and infant growth characteristics with the risks of preschool wheezing (1-4 years) and school-age asthma (5-10 years). METHODS: First, we performed an adjusted 1-stage random-effect meta-analysis to assess the combined associations of gestational age, birth weight, and infant weight gain with childhood asthma. Second, we performed an adjusted 2-stage random-effect meta-analysis to assess the associations of preterm birth (gestational age <37 weeks) and low birth weight (<2500 g) with childhood asthma outcomes. RESULTS: Younger gestational age at birth and higher infant weight gain were independently associated with higher risks of preschool wheezing and school-age asthma (P < .05). The inverse associations of birth weight with childhood asthma were explained by gestational age at birth. Compared with term-born children with normal infant weight gain, we observed the highest risks of school-age asthma in children born preterm with high infant weight gain (odds ratio [OR], 4.47; 95% CI, 2.58-7.76). Preterm birth was positively associated with an increased risk of preschool wheezing (pooled odds ratio [pOR], 1.34; 95% CI, 1.25-1.43) and school-age asthma (pOR, 1.40; 95% CI, 1.18-1.67) independent of birth weight. Weaker effect estimates were observed for the associations of low birth weight adjusted for gestational age at birth with preschool wheezing (pOR, 1.10; 95% CI, 1.00-1.21) and school-age asthma (pOR, 1.13; 95% CI, 1.01-1.27). CONCLUSION: Younger gestational age at birth and higher infant weight gain were associated with childhood asthma outcomes. The associations of lower birth weight with childhood asthma were largely explained by gestational age at birth.  
  Address Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Paediatrics, Division of Respiratory Medicine, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Paediatrics, Division of Neonatology, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: l.duijts@erasmusmc.nl  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Sonnenschein-van der Voort, A.M.M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Duijts, L.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:24529685; PMCID:PMC4024198 Approved no  
  Call Number Serial 42  
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