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Author Muc, M.; Kreiner-Moller, E.; Larsen, J.M.; Birch, S.; Brix, S.; Bisgaard, H.; Lauritzen, L. url  doi
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  Title Maternal fatty acid desaturase genotype correlates with infant immune responses at 6 months Type Journal Article
  Year (down) 2015 Publication The British Journal of Nutrition Abbreviated Journal Br J Nutr  
  Volume 114 Issue 6 Pages 891-898  
  Keywords AA arachidonic acid; Adaptive immunity; Breast-feeding; CD cluster of differentiation; FADS fatty acid desaturase gene cluster; GLA gamma-linolenic acid; IFN-gamma interferon-gamma; Infants; LCPUFA long-chain PUFA; Long-chain PUFA; Mendelian randomisation analysis; PBMC peripheral blood mononuclear cells; PC principal component; PCA principal component analysis; Tc cytotoxic T-cell; Th T-helper cell; Treg regulatory T-cell  
  Abstract Breast milk long-chain PUFA (LCPUFA) have been associated with changes in early life immune responses and may modulate T-cell function in infancy. We studied the effect of maternal fatty acid desaturase (FADS) genotype and breast milk LCPUFA levels on infants' blood T-cell profiles and ex vivo-produced cytokines after anti-CD3/CD28 stimulation of peripheral blood mononuclear cells in 6-month-old infants from the Copenhagen Prospective Study of Asthma in Childhood birth cohort. LCPUFA concentrations of breast milk were assessed at 4 weeks of age, and FADS SNP were determined in both mothers and infants (n 109). In general, breast milk arachidonic acid (AA) levels were inversely correlated with the production of IL-10 (r -0.25; P=0.004), IL-17 (r -0.24; P=0.005), IL-5 (r -0.21; P=0.014) and IL-13 (r -0.17; P=0.047), whereas EPA was positively correlated with the counts of blood regulatory T-cells and cytotoxic T-cells and decreased T-helper cell counts. The minor FADS alleles were associated with lower breast milk AA and EPA, and infants of mothers carrying the minor allele of FADS SNP rs174556 had higher production of IL-10 (r -0.23; P=0.018), IL-17 (r -0.25; P=0.009) and IL-5 (r -0.21; P=0.038) from ex vivo-activated immune cells. We observed no association between T-cell distribution and maternal or infant FADS gene variants. We conclude that increased maternal LCPUFA synthesis and breast milk AA are associated with decreased levels of IL-5, IL-13 (type-2 related), IL-17 (type-17 related) and IL-10 (regulatory immune responses), but not with interferon-gamma and TNF-alpha, which could be due to an effect of the maternal FADS variants on the offspring immune response transferred via breast milk LCPUFA.  
  Address 4Department of Nutrition,Exercise and Sports,University of Copenhagen,1958 Frederiksberg,Denmark  
  Corporate Author Thesis  
  Impact Factor 03,453 First Author Muc, M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Lauritzen, L.  
  ISSN 0007-1145 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26283408 Approved no  
  Call Number Serial 38  
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