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Author Demenais, F.; Margaritte-Jeannin, P.; Barnes, K.C.; Cookson, W.O.C.; Altmuller, J.; Ang, W.; Barr, R.G.; Beaty, T.H.; Becker, A.B.; Beilby, J.; Bisgaard, H.; Bjornsdottir, U.S.; Bleecker, E.; Bonnelykke, K.; Boomsma, D.I.; Bouzigon, E.; Brightling, C.E.; Brossard, M.; Brusselle, G.G.; Burchard, E.; Burkart, K.M.; Bush, A.; Chan-Yeung, M.; Chung, K.F.; Couto Alves, A.; Curtin, J.A.; Custovic, A.; Daley, D.; de Jongste, J.C.; Del-Rio-Navarro, B.E.; Donohue, K.M.; Duijts, L.; Eng, C.; Eriksson, J.G.; Farrall, M.; Fedorova, Y.; Feenstra, B.; Ferreira, M.A.; Freidin, M.B.; Gajdos, Z.; Gauderman, J.; Gehring, U.; Geller, F.; Genuneit, J.; Gharib, S.A.; Gilliland, F.; Granell, R.; Graves, P.E.; Gudbjartsson, D.F.; Haahtela, T.; Heckbert, S.R.; Heederik, D.; Heinrich, J.; Heliovaara, M.; Henderson, J.; Himes, B.E.; Hirose, H.; Hirschhorn, J.N.; Hofman, A.; Holt, P.; Hottenga, J.; Hudson, T.J.; Hui, J.; Imboden, M.; Ivanov, V.; Jaddoe, V.W.V.; James, A.; Janson, C.; Jarvelin, M.-R.; Jarvis, D.; Jones, G.; Jonsdottir, I.; Jousilahti, P.; Kabesch, M.; Kahonen, M.; Kantor, D.B.; Karunas, A.S.; Khusnutdinova, E.; Koppelman, G.H.; Kozyrskyj, A.L.; Kreiner, E.; Kubo, M.; Kumar, R.; Kumar, A.; Kuokkanen, M.; Lahousse, L.; Laitinen, T.; Laprise, C.; Lathrop, M.; Lau, S.; Lee, Y.-A.; Lehtimaki, T.; Letort, S.; Levin, A.M.; Li, G.; Liang, L.; Loehr, L.R.; London, S.J.; Loth, D.W.; Manichaikul, A.; Marenholz, I.; Martinez, F.J.; Matheson, M.C.; Mathias, R.A.; Matsumoto, K.; Mbarek, H.; McArdle, W.L.; Melbye, M.; Melen, E.; Meyers, D.; Michel, S.; Mohamdi, H.; Musk, A.W.; Myers, R.A.; Nieuwenhuis, M.A.E.; Noguchi, E.; O'Connor, G.T.; Ogorodova, L.M.; Palmer, C.D.; Palotie, A.; Park, J.E.; Pennell, C.E.; Pershagen, G.; Polonikov, A.; Postma, D.S.; Probst-Hensch, N.; Puzyrev, V.P.; Raby, B.A.; Raitakari, O.T.; Ramasamy, A.; Rich, S.S.; Robertson, C.F.; Romieu, I.; Salam, M.T.; Salomaa, V.; Schlunssen, V.; Scott, R.; Selivanova, P.A.; Sigsgaard, T.; Simpson, A.; Siroux, V.; Smith, L.J.; Solodilova, M.; Standl, M.; Stefansson, K.; Strachan, D.P.; Stricker, B.H.; Takahashi, A.; Thompson, P.J.; Thorleifsson, G.; Thorsteinsdottir, U.; Tiesler, C.M.T.; Torgerson, D.G.; Tsunoda, T.; Uitterlinden, A.G.; van der Valk, R.J.P.; Vaysse, A.; Vedantam, S.; von Berg, A.; von Mutius, E.; Vonk, J.M.; Waage, J.; Wareham, N.J.; Weiss, S.T.; White, W.B.; Wickman, M.; Widen, E.; Willemsen, G.; Williams, L.K.; Wouters, I.M.; Yang, J.J.; Zhao, J.H.; Moffatt, M.F.; Ober, C.; Nicolae, D.L. url  doi
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  Title Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks Type Journal Article
  Year (down) 2018 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 50 Issue 1 Pages 42-53  
  Keywords  
  Abstract We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.  
  Address Departments of Statistics, Human Genetics and Medicine, Section of Genetic Medicine, University of Chicago, Chicago, IL, USA. nicolae@galton.uchicago.edu  
  Corporate Author Australian Asthma Genetics Consortium (AAGC) collaborators Thesis  
  Impact Factor 31,616 First Author Demenais, F. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Nicolae, D.L.  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29273806 Approved no  
  Call Number Serial 369  
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