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Author Barban, N.; Jansen, R.; de Vlaming, R.; Vaez, A.; Mandemakers, J.J.; Tropf, F.C.; Shen, X.; Wilson, J.F.; Chasman, D.I.; Nolte, I.M.; Tragante, V.; van der Laan, S.W.; Perry, J.R.B.; Kong, A.; Ahluwalia, T.S.; Albrecht, E.; Yerges-Armstrong, L.; Atzmon, G.; Auro, K.; Ayers, K.; Bakshi, A.; Ben-Avraham, D.; Berger, K.; Bergman, A.; Bertram, L.; Bielak, L.F.; Bjornsdottir, G.; Bonder, M.J.; Broer, L.; Bui, M.; Barbieri, C.; Cavadino, A.; Chavarro, J.E.; Turman, C.; Concas, M.P.; Cordell, H.J.; Davies, G.; Eibich, P.; Eriksson, N.; Esko, T.; Eriksson, J.; Falahi, F.; Felix, J.F.; Fontana, M.A.; Franke, L.; Gandin, I.; Gaskins, A.J.; Gieger, C.; Gunderson, E.P.; Guo, X.; Hayward, C.; He, C.; Hofer, E.; Huang, H.; Joshi, P.K.; Kanoni, S.; Karlsson, R.; Kiechl, S.; Kifley, A.; Kluttig, A.; Kraft, P.; Lagou, V.; Lecoeur, C.; Lahti, J.; Li-Gao, R.; Lind, P.A.; Liu, T.; Makalic, E.; Mamasoula, C.; Matteson, L.; Mbarek, H.; McArdle, P.F.; McMahon, G.; Meddens, S.F.W.; Mihailov, E.; Miller, M.; Missmer, S.A.; Monnereau, C.; van der Most, P.J.; Myhre, R.; Nalls, M.A.; Nutile, T.; Kalafati, I.P.; Porcu, E.; Prokopenko, I.; Rajan, K.B.; Rich-Edwards, J.; Rietveld, C.A.; Robino, A.; Rose, L.M.; Rueedi, R.; Ryan, K.A.; Saba, Y.; Schmidt, D.; Smith, J.A.; Stolk, L.; Streeten, E.; Tonjes, A.; Thorleifsson, G.; Ulivi, S.; Wedenoja, J.; Wellmann, J.; Willeit, P.; Yao, J.; Yengo, L.; Zhao, J.H.; Zhao, W.; Zhernakova, D.V.; Amin, N.; Andrews, H.; Balkau, B.; Barzilai, N.; Bergmann, S.; Biino, G.; Bisgaard, H.; Bonnelykke, K.; Boomsma, D.I.; Buring, J.E.; Campbell, H.; Cappellani, S.; Ciullo, M.; Cox, S.R.; Cucca, F.; Toniolo, D.; Davey-Smith, G.; Deary, I.J.; Dedoussis, G.; Deloukas, P.; van Duijn, C.M.; de Geus, E.J.C.; Eriksson, J.G.; Evans, D.A.; Faul, J.D.; Sala, C.F.; Froguel, P.; Gasparini, P.; Girotto, G.; Grabe, H.-J.; Greiser, K.H.; Groenen, P.J.F.; de Haan, H.G.; Haerting, J.; Harris, T.B.; Heath, A.C.; Heikkila, K.; Hofman, A.; Homuth, G.; Holliday, E.G.; Hopper, J.; Hypponen, E.; Jacobsson, B.; Jaddoe, V.W.V.; Johannesson, M.; Jugessur, A.; Kahonen, M.; Kajantie, E.; Kardia, S.L.R.; Keavney, B.; Kolcic, I.; Koponen, P.; Kovacs, P.; Kronenberg, F.; Kutalik, Z.; La Bianca, M.; Lachance, G.; Iacono, W.G.; Lai, S.; Lehtimaki, T.; Liewald, D.C.; Lindgren, C.M.; Liu, Y.; Luben, R.; Lucht, M.; Luoto, R.; Magnus, P.; Magnusson, P.K.E.; Martin, N.G.; McGue, M.; McQuillan, R.; Medland, S.E.; Meisinger, C.; Mellstrom, D.; Metspalu, A.; Traglia, M.; Milani, L.; Mitchell, P.; Montgomery, G.W.; Mook-Kanamori, D.; de Mutsert, R.; Nohr, E.A.; Ohlsson, C.; Olsen, J.; Ong, K.K.; Paternoster, L.; Pattie, A.; Penninx, B.W.J.H.; Perola, M.; Peyser, P.A.; Pirastu, M.; Polasek, O.; Power, C.; Kaprio, J.; Raffel, L.J.; Raikkonen, K.; Raitakari, O.; Ridker, P.M.; Ring, S.M.; Roll, K.; Rudan, I.; Ruggiero, D.; Rujescu, D.; Salomaa, V.; Schlessinger, D.; Schmidt, H.; Schmidt, R.; Schupf, N.; Smit, J.; Sorice, R.; Spector, T.D.; Starr, J.M.; Stockl, D.; Strauch, K.; Stumvoll, M.; Swertz, M.A.; Thorsteinsdottir, U.; Thurik, A.R.; Timpson, N.J.; Tung, J.Y.; Uitterlinden, A.G.; Vaccargiu, S.; Viikari, J.; Vitart, V.; Volzke, H.; Vollenweider, P.; Vuckovic, D.; Waage, J.; Wagner, G.G.; Wang, J.J.; Wareham, N.J.; Weir, D.R.; Willemsen, G.; Willeit, J.; Wright, A.F.; Zondervan, K.T.; Stefansson, K.; Krueger, R.F.; Lee, J.J.; Benjamin, D.J.; Cesarini, D.; Koellinger, P.D.; den Hoed, M.; Snieder, H.; Mills, M.C. url  doi
openurl 
  Title Genome-wide analysis identifies 12 loci influencing human reproductive behavior Type Journal Article
  Year (down) 2016 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 48 Issue 12 Pages 1462-1472  
  Keywords *Birth Order; Female; Fertility/genetics; *Genome-Wide Association Study; Humans; Maternal Age; Parity/*genetics; Phenotype; Polymorphism, Single Nucleotide/genetics; Pregnancy; *Quantitative Trait Loci; Reproduction/*genetics; Reproductive Behavior/*physiology  
  Abstract The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB. We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort. These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits.  
  Address Department of Sociology and Nuffield College, University of Oxford, Oxford, UK  
  Corporate Author LifeLines Cohort Study Thesis  
  Impact Factor 31,616 First Author Barban, N. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Mills, MC.  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27798627 Approved no  
  Call Number Serial 353  
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