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Author Horikoshi, M.; Beaumont, R.N.; Day, F.R.; Warrington, N.M.; Kooijman, M.N.; Fernandez-Tajes, J.; Feenstra, B.; van Zuydam, N.R.; Gaulton, K.J.; Grarup, N.; Bradfield, J.P.; Strachan, D.P.; Li-Gao, R.; Ahluwalia, T.S.; Kreiner, E.; Rueedi, R.; Lyytikainen, L.-P.; Cousminer, D.L.; Wu, Y.; Thiering, E.; Wang, C.A.; Have, C.T.; Hottenga, J.-J.; Vilor-Tejedor, N.; Joshi, P.K.; Boh, E.T.H.; Ntalla, I.; Pitkanen, N.; Mahajan, A.; van Leeuwen, E.M.; Joro, R.; Lagou, V.; Nodzenski, M.; Diver, L.A.; Zondervan, K.T.; Bustamante, M.; Marques-Vidal, P.; Mercader, J.M.; Bennett, A.J.; Rahmioglu, N.; Nyholt, D.R.; Ma, R.C.W.; Tam, C.H.T.; Tam, W.H.; Ganesh, S.K.; van Rooij, F.J.A.; Jones, S.E.; Loh, P.-R.; Ruth, K.S.; Tuke, M.A.; Tyrrell, J.; Wood, A.R.; Yaghootkar, H.; Scholtens, D.M.; Paternoster, L.; Prokopenko, I.; Kovacs, P.; Atalay, M.; Willems, S.M.; Panoutsopoulou, K.; Wang, X.; Carstensen, L.; Geller, F.; Schraut, K.E.; Murcia, M.; van Beijsterveldt, C.E.M.; Willemsen, G.; Appel, E.V.R.; Fonvig, C.E.; Trier, C.; Tiesler, C.M.T.; Standl, M.; Kutalik, Z.; Bonas-Guarch, S.; Hougaard, D.M.; Sanchez, F.; Torrents, D.; Waage, J.; Hollegaard, M.V.; de Haan, H.G.; Rosendaal, F.R.; Medina-Gomez, C.; Ring, S.M.; Hemani, G.; McMahon, G.; Robertson, N.R.; Groves, C.J.; Langenberg, C.; Luan, J.'an; Scott, R.A.; Zhao, J.H.; Mentch, F.D.; MacKenzie, S.M.; Reynolds, R.M.; Lowe, W.L.; Tonjes, A.; Stumvoll, M.; Lindi, V.; Lakka, T.A.; van Duijn, C.M.; Kiess, W.; Korner, A.; Sorensen, T.I.A.; Niinikoski, H.; Pahkala, K.; Raitakari, O.T.; Zeggini, E.; Dedoussis, G.V.; Teo, Y.-Y.; Saw, S.-M.; Melbye, M.; Campbell, H.; Wilson, J.F.; Vrijheid, M.; de Geus, E.J.C.N.; Boomsma, D.I.; Kadarmideen, H.N.; Holm, J.-C.; Hansen, T.; Sebert, S.; Hattersley, A.T.; Beilin, L.J.; Newnham, J.P.; Pennell, C.E.; Heinrich, J.; Adair, L.S.; Borja, J.B.; Mohlke, K.L.; Eriksson, J.G.; Widen, E.; Kahonen, M.; Viikari, J.S.; Lehtimaki, T.; Vollenweider, P.; Bonnelykke, K.; Bisgaard, H.; Mook-Kanamori, D.O.; Hofman, A.; Rivadeneira, F.; Uitterlinden, A.G.; Pisinger, C.; Pedersen, O.; Power, C.; Hypponen, E.; Wareham, N.J.; Hakonarson, H.; Davies, E.; Walker, B.R.; Jaddoe, V.W.V.; Jarvelin, M.-R.; Grant, S.F.A.; Vaag, A.A.; Lawlor, D.A.; Frayling, T.M.; Smith, G.D.; Morris, A.P.; Ong, K.K.; Felix, J.F.; Timpson, N.J.; Perry, J.R.B.; Evans, D.M.; McCarthy, M.I.; Freathy, R.M. url  doi
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  Title Genome-wide associations for birth weight and correlations with adult disease Type Journal Article
  Year (down) 2016 Publication Nature Abbreviated Journal Nature  
  Volume 538 Issue 7624 Pages 248-252  
  Keywords  
  Abstract Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 x 10-8). Overall, approximately 15% of variance in BW was captured by assays of fetal genetic variation. Using genetic association alone, we found strong inverse genetic correlations between BW and systolic blood pressure (Rg = -0.22, P = 5.5 x 10-13), T2D (Rg = -0.27, P = 1.1 x 10-6) and coronary artery disease (Rg = -0.30, P = 6.5 x 10-9). In addition, using large -cohort datasets, we demonstrated that genetic factors were the major contributor to the negative covariance between BW and future cardiometabolic risk. Pathway analyses indicated that the protein products of genes within BW-associated regions were enriched for diverse processes including insulin signalling, glucose homeostasis, glycogen biosynthesis and chromatin remodelling. There was also enrichment of associations with BW in known imprinted regions (P = 1.9 x 10-4). We demonstrate that life-course associations between early growth phenotypes and adult cardiometabolic disease are in part the result of shared genetic effects and identify some of the pathways through which these causal genetic effects are mediated.  
  Address Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol BS8 2BN, UK  
  Corporate Author Early Growth Genetics (EGG) Consortium Thesis  
  Impact Factor 41,456 First Author Horikoshi, M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Freathy, R.M.  
  ISSN 0028-0836 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27680694 Approved no  
  Call Number Serial 333  
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