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Author Jepsen, A.A.; Chawes, B.L.; Carson, C.G.; Schoos, A.-M.M.; Thysen, A.H.; Waage, J.; Brix, S.; Bisgaard, H. url  doi
  Title High Breast Milk IL-1beta Level is Associated with Reduced Risk of Childhood Eczema Type Journal Article
  Year (down) 2016 Publication Clinical and Experimental Allergy Abbreviated Journal Clin Exp Allergy  
  Volume 46 Issue Pages 1344-1354  
  Keywords breastfeeding; chemokines; cytokines; eczema; immune mediators  
  Abstract BACKGROUND: We recently demonstrated a dual effect of breastfeeding with increased risk of eczema and decreased risk of wheezing in early childhood by increasing breastfeeding length. We hypothesize that immune mediators in breast milk could explain such association either through a direct effect or as a surrogate marker of maternal immune constitution. OBJECTIVE: To investigate the possible association between cytokine and chemokine levels in breast milk and development of eczema and recurrent wheeze during early childhood. METHODS: Levels of 19 pro-inflammatory and immune-regulatory cytokines and chemokines were measured in 223 breast milk samples from mothers in the Copenhagen Prospective Study on Asthma in Childhood2000 high-risk birth cohort. Eczema and recurrent wheeze at age 0-3 years were prospectively diagnosed by COPSAC pediatricians adherent to predefined validated algorithms. Association analyses were performed by Cox regression adjusting for potential confounding factors and by multivariable principle component analysis. RESULTS: Increased IL-1beta in breast milk (>/=0.7 pg/mL) was associated with more than a halved risk of eczema before age three (aHR=0.41; 95%CI=0.24-0.68; p<0.001), which remained significant after false discovery rate adjustment (p=0.008). The principle component analysis confirmed that a mediator pattern dominated by high IL-1beta, IL-17A, and CCL17 and low CXCL1 and TSLP in breast milk protected against eczema (aHR=0.82; 95%CI=0.68-0.98; p=0.03). No associations were observed for recurrent wheeze. CONCLUSIONS AND CLINICAL RELEVANCE: Elevated maternal breast milk IL-1beta associated with decreased risk of early childhood eczema suggesting IL-1beta as a proxy for a healthy maternal immune system protecting high-risk offspring from eczema, or through a direct effect on the infant. This article is protected by copyright. All rights reserved.  
  Address COPSAC; Copenhagen Prospective Study on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 04,769 First Author Jepsen, A.A. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0954-7894 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27251401 Approved no  
  Call Number Serial 324  
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