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Author Wolsk, H.M.; Folsgaard, N.V.; Birch, S.; Brix, S.; Hansel, T.T.; Johnston, S.L.; Kebadze, T.; Chawes, B.L.; Bonnelykke, K.; Bisgaard, H. url  doi
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  Title Picornavirus-Induced Airway Mucosa Immune Profile in Asymptomatic Neonates Type Journal Article
  Year (down) 2016 Publication The Journal of Infectious Diseases Abbreviated Journal J Infect Dis  
  Volume 213 Issue 8 Pages 1262-1270  
  Keywords chemokines; children; cytokines; mucosal lining fluid; virus  
  Abstract BACKGROUND: Bacterial airway colonization is known to alter the airway mucosa immune response in neonates whereas the impact of viruses is unknown. The objective was therefore to examine the effect of respiratory viruses on the immune signature in the airways of asymptomatic neonates. METHODS: Nasal aspirates from 571 asymptomatic 1-month-old neonates from the Copenhagen Prospective Studies on Asthma in Childhood 2010 birth cohort were investigated for respiratory viruses. Simultaneously, unstimulated airway mucosal lining fluid was obtained and quantified for levels of 20 immune mediators related to type 1, type 2, type 17, and regulatory immune paths. The association between immune mediator levels and viruses was tested by conventional statistics and partial least square discriminant analysis. RESULTS: Picornaviruses were detected in 58 neonates (10.2%) and other viruses in 10 (1.8%). A general up-regulation of immune mediators was found in the neonates with picornavirus (P < .0001; partial least square discriminant analysis). The association was pronounced for type 1- and type 2-related markers and was unaffected by comprehensive confounder adjustment. Detection of picornavirus and bacteria was associated with an additive general up-regulating effect. CONCLUSIONS: Asymptomatic presence of picornavirus in the neonatal airway is a potent activator of the topical immune response. This is relevant to understanding the immune potentiating effect of early life exposure to viruses.  
  Address COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen  
  Corporate Author Thesis  
  Impact Factor 05,997 First Author Wolsk, H.M. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0022-1899 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26655299 Approved no  
  Call Number Serial 323  
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