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Author Paternoster, L.; Standl, M.; Waage, J.; Baurecht, H.; Hotze, M.; Strachan, D.P.; Curtin, J.A.; Bonnelykke, K.; Tian, C.; Takahashi, A.; Esparza-Gordillo, J.; Alves, A.C.; Thyssen, J.P.; den Dekker, H.T.; Ferreira, M.A.; Altmaier, E.; Sleiman, P.M.A.; Xiao, F.L.; Gonzalez, J.R.; Marenholz, I.; Kalb, B.; Pino-Yanes, M.; Xu, C.-J.; Carstensen, L.; Groen-Blokhuis, M.M.; Venturini, C.; Pennell, C.E.; Barton, S.J.; Levin, A.M.; Curjuric, I.; Bustamante, M.; Kreiner-Moller, E.; Lockett, G.A.; Bacelis, J.; Bunyavanich, S.; Myers, R.A.; Matanovic, A.; Kumar, A.; Tung, J.Y.; Hirota, T.; Kubo, M.; McArdle, W.L.; Henderson, A.J.; Kemp, J.P.; Zheng, J.; Smith, G.D.; Ruschendorf, F.; Bauerfeind, A.; Lee-Kirsch, M.A.; Arnold, A.; Homuth, G.; Schmidt, C.O.; Mangold, E.; Cichon, S.; Keil, T.; Rodriguez, E.; Peters, A.; Franke, A.; Lieb, W.; Novak, N.; Folster-Holst, R.; Horikoshi, M.; Pekkanen, J.; Sebert, S.; Husemoen, L.L.; Grarup, N.; de Jongste, J.C.; Rivadeneira, F.; Hofman, A.; Jaddoe, V.W.V.; Pasmans, S.G.M.A.; Elbert, N.J.; Uitterlinden, A.G.; Marks, G.B.; Thompson, P.J.; Matheson, M.C.; Robertson, C.F.; Ried, J.S.; Li, J.; Zuo, X.B.; Zheng, X.D.; Yin, X.Y.; Sun, L.D.; McAleer, M.A.; O'Regan, G.M.; Fahy, C.M.R.; Campbell, L.E.; Macek, M.; Kurek, M.; Hu, D.; Eng, C.; Postma, D.S.; Feenstra, B.; Geller, F.; Hottenga, J.J.; Middeldorp, C.M.; Hysi, P.; Bataille, V.; Spector, T.; Tiesler, C.M.T.; Thiering, E.; Pahukasahasram, B.; Yang, J.J.; Imboden, M.; Huntsman, S.; Vilor-Tejedor, N.; Relton, C.L.; Myhre, R.; Nystad, W.; Custovic, A.; Weiss, S.T.; Meyers, D.A.; Soderhall, C.; Melen, E.; Ober, C.; Raby, B.A.; Simpson, A.; Jacobsson, B.; Holloway, J.W.; Bisgaard, H.; Sunyer, J.; Probst-Hensch, N.M.; Williams, L.K.; Godfrey, K.M.; Wang, C.A.; Boomsma, D.I.; Melbye, M.; Koppelman, G.H.; Jarvis, D.; McLean, W.H.I.; Irvine, A.D.; Zhang, X.J.; Hakonarson, H.; Gieger, C.; Burchard, E.G.; Martin, N.G.; Duijts, L.; Linneberg, A.; Jarvelin, M.-R.; Nothen, M.M.; Lau, S.; Hubner, N.; Lee, Y.-A.; Tamari, M.; Hinds, D.A.; Glass, D.; Brown, S.J.; Heinrich, J.; Evans, D.M.; Weidinger, S. url  doi
openurl 
  Title Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis Type Journal Article
  Year (down) 2015 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 47 Issue 12 Pages 1449-1456  
  Keywords  
  Abstract Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto)immune mechanisms to atopic dermatitis pathogenesis.  
  Address  
  Corporate Author EArly Genetics and Lifecourse Epidemiology (EAGLE) Eczema Consortium Thesis  
  Impact Factor 29,352 First Author Paternoster, L. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Weidinger, S.  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:26482879; PMCID:PMC4753676 Approved no  
  Call Number Serial 320  
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