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Author Gronbaek, J.; Hallas, H.W.; Arianto, L.; Pedersen, K.; Thomsen, A.; Chawes, B.; Bisgaard, H. url  doi
openurl 
  Title New timesaving predictor-algorithm for Multiple Breath Wash-out in Adolescents Type Journal Article
  Year (down) 2016 Publication Pediatric Research Abbreviated Journal Pediatr Res  
  Volume 8 Issue 1 Pages 49-53  
  Keywords  
  Abstract BACKGROUND: Multiple Breath Wash-out (MBW) is an informative but time consuming test. This study evaluates the uncertainty of a time saving predictor algorithm in adolescents. METHODS: Adolescents were recruited from the Copenhagen Prospective Study on Asthma in Childhood (COPSAC2000) birth cohort. MBW trials were performed at age 13 years with Innocor model Inn00400 using sulfur hexafluoride (SF6) as tracer gas. Measurements were analyzed using a mixed model focusing on two prediction points doubling (t5%) and quadrupling (t10%) the standard end-point (t2.5%). RESULTS: One-hundred-seventy-two MBW trials conducted in 78 adolescents with and without asthma from COPSAC2000 were included. At t10% the wash-out time was reduced by 41% and an uncertainty of 0.159 Lung Clearance Index (LCI) units was introduced (+/-2 standard deviations (SD)), +/-1.27). At t5% the wash-out time was reduced by 25%, with an uncertainty of 0.083 LCI-units (+/-0.558). The optimal prediction point, which led to most time saved and least uncertainty was t5%. CONCLUSION: The predictor algorithm is capable of shortening the MBW test time, but introduces an increasing uncertainty with earlier prediction points. This first-of-a-kind prediction algorithm holds promise in shortening the MBW test in children, but should be used with caution in subjects with normal LCI values.Pediatric Research (2016); doi:10.1038/pr.2016.57.  
  Address COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 02,314 First Author Gronbaek, J. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0031-3998 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:27002983 Approved no  
  Call Number Serial 312  
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