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Author Bisgaard, H.; Poulsen, L.; Sondergaard, I. url  openurl
  Title Nebulization and selective deposition of LTD4 in human lungs Type Journal Article
  Year (down) 1987 Publication Allergy Abbreviated Journal Allergy  
  Volume 42 Issue 5 Pages 336-342  
  Keywords Adult; Aerosols; Asthma/diagnosis; Bronchial Provocation Tests; Chromatography, High Pressure Liquid; Female; Forced Expiratory Volume; Humans; Lung/*metabolism; Male; Nebulizers and Vaporizers; Pulmonary Ventilation; *SRS-A/administration & dosage  
  Abstract The process of nebulization and deposition of LTD4 was studied in detail. The concentration of LTD4 in a saline solution decreased by approximately 90% after 2 min of nebulization in a DeVilbiss 35B ultrasonic nebulizer. This decrease was prevented by diluting LTD4 in a phosphate buffer, pH 7.4. Nebulization of tritiated LTD4 in this phosphate buffer did not cause any appreciable deterioration of the leukotriene, as demonstrated by an unchanged ratio between radioactivity and LTD4 concentration in the test solution before and after nebulization as well as in the condensed aerosol. The aerosol generated by the DeVilbiss 35B ultrasonic nebulizer was shown to generate particles with a mass median diameter of 1.3 microns (dry particle size). Interposition of a settling bag reduced the amount of large particles, reducing the mass median diameter to 0.84 microns (dry particle size). Nine healthy volunteers were challenged on separate days with 40 nmol LTD4 or 100 mumol histamine, and the changes in FEV1 and partial flow volume curves initiated at 50% of vital capacity (Vmax30) were measured. A relative diffuse deposition pattern was ensured by inhalation via a settling bag. These results were compared to challenges with a relatively central deposition pattern as ensured by inhalation directly from the nebulizer with brisk inhalation maneuvers. The diffuse deposition pattern caused minimal changes in FEV1 but pronounced effect in Vmax30. The effects of LTD4 and histamine on FEV1 and Vmax30 changed in parallel when the deposition of the mediators was changed to a more central pattern. This indicates that the two mediators do not differ with respect to any selective effects on different parts of the airways.  
  Address  
  Corporate Author Thesis  
  Impact Factor 06,028 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Sondergaard, I.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:3631461 Approved no  
  Call Number Serial 303  
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