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Author Bisgaard, H.; Groth, S. url  openurl
  Title Bronchial effects of leukotriene D4 inhalation in normal human lung Type Journal Article
  Year (down) 1987 Publication Clinical Science Abbreviated Journal Clin Sci  
  Volume 72 Issue 5 Pages 585-592  
  Keywords Airway Resistance/*drug effects; Bronchi/*drug effects; Bronchial Provocation Tests; Dose-Response Relationship, Drug; Histamine/pharmacology; Humans; Ipratropium/pharmacology; SRS-A/*pharmacology  
  Abstract The aim of the study was to investigate whether inhaled leukotriene (LT) D4 could mimic the characteristics of asthmatic patients after allergen-induced attack, i.e. a prolonged subclinical bronchial obstruction, an increased reactivity of the airways and a late reaction. The effects of LTD4 were compared with those of histamine and the mechanism of action sought. Thirty-three non-atopic individuals participated in the study. The two drugs were inhaled as an aerosol of small particles causing a relative peripheral deposition pattern in order to mimic the preferential involvement of peripheral airways in asthmatic patients out of attack. LTD4 caused a dose-dependent obstruction of the airways as measured by partial flow-volume curves and volume of trapped gas, yet only minor changes in forced expiratory volume in 1 s (FEV1) and peak expiratory flow rate. LTD4 was 1900-7000 times more potent than histamine. LTD4 inhalations were almost symptomless as opposed to the irritative and dyspnoeic symptoms seen after inhalation of histamine. The time duration for the induced change in partial flow-volume curves was the same for the two drugs. Approximately 30 min elapsed until the bronchial obstruction had decreased by 50% of the maximum effect, and no delayed reaction was observed within 10 h. The reactivity of the airways did not change during 10 h after inhalation of LTD4 as tested by repeated exercise challenges. Pretreatment with ipratropium bromide prevented the effect of LTD4 on FEV1, yet not on partial flow-volume curves. Pretreatment with either cimetidine and mepyramine or with indomethacin, did not affect the bronchial obstruction after LTD4.(ABSTRACT TRUNCATED AT 250 WORDS)  
  Corporate Author Thesis  
  Impact Factor 05,598 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Groth, S.  
  ISSN 0143-5221 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:2953527 Approved no  
  Call Number Serial 302  
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