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Author Stafanger, G.; Bisgaard, H.; Pedersen, M.; Morkassel, E.; Koch, C. url  openurl
  Title Effect of N-acetylcysteine on the human nasal ciliary activity in vitro Type Journal Article
  Year (down) 1987 Publication European Journal of Respiratory Diseases Abbreviated Journal Eur J Respir Dis  
  Volume 70 Issue 3 Pages 157-162  
  Keywords Acetylcysteine/*pharmacology; Cilia/*drug effects; Humans; In Vitro Techniques; Movement/drug effects; Nasal Mucosa/*drug effects; Perfusion  
  Abstract N-acetylcysteine (NAC) is widely used as a mucolytic agent, but the clinical and pharmacological effects of NAC are still unclear. It has recently been claimed in animal studies that NAC will stimulate ciliary beating frequency at low concentrations, while inhibiting beating at higher concentrations. Using a microphoto-oscillographic method combined with microperfusion technique, we studied the direct effect of NAC on human nasal cilia. NAC caused a direct dose- and time-related decrease in ciliary beating frequency, which was detectable at 2 mg/ml and reached statistically significant levels at 20 mg/ml. NAC at 200 mg/ml caused total cessation of movements within 15 s but this effect was completely reversible within 15 min of perfusion with medium alone. At no concentrations of NAC was beating frequency increased over base-line. NAC, however, had no effect on beating pattern. NAC seems to have a selective and fully reversible inhibitory effect on the beating frequency of human cilia in vitro.  
  Address  
  Corporate Author Thesis  
  Impact Factor 05,339 First Author Stafanger, G. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Koch, C.  
  ISSN 0106-4339 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:3569447 Approved no  
  Call Number Serial 301  
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