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Author Bisgaard, H. url  openurl
  Title Vascular effects of leukotriene D4 in human skin Type Journal Article
  Year (down) 1987 Publication The Journal of Investigative Dermatology Abbreviated Journal J Invest Dermatol  
  Volume 88 Issue 2 Pages 109-114  
  Keywords Adolescent; Adult; Female; Histamine/pharmacology; Histamine Antagonists/pharmacology; Humans; Indomethacin/pharmacology; Male; Middle Aged; Nerve Block; Pressoreceptors/physiology; SRS-A/*pharmacology; Skin/blood supply/*drug effects/innervation; Skin Tests; Valsalva Maneuver; Vasodilation/drug effects  
  Abstract Leukotriene D4 (LTD4) increased the blood flow rate in human skin, equipotent to histamine in the dose range of 3.1-200 pmol. The vasodilatation lasted for up to 60 min, and no late reactions occurred. Indomethacin did not affect the LTD4-induced blood flow rate. H1 and H2 antagonists reduced the increase in blood flow rate, but did not abolish the response to LTD4. Local nerve block inhibited the axon reflex-mediated flare component of the LTD4-induced blood flow rate, leaving a local red reaction. This local red reaction was not affected by H1 and H2 antagonists. These results indicate histamine as a mediator of the axon reflex, and show that LTD4 causes a direct vasodilatory effect that is not mediated via histamine or cyclooxygenase products. The laser-Doppler flowmeter was applied for dynamic studies of the vasopressor response in the skin during a Valsalva maneuver, and the relative changes in blood flow were confirmed by control estimates of the blood flow rate by a 133xenon washout method. The pressor response to a Valsalva maneuver was reversed by local nerve block, but not affected by LTD4. Therefore LTD4 did not interfere with the sympathetic activity on the cutaneous vessels. Leukotriene D4 caused a dose-dependent wheal reaction, equipotent to histamine in the dose range of 0.2-200 pmol. Only minor whealing occurred when the vasculature to the test arm was occluded before injection of LTD4 and the circulation restored 30 min later. Most of the LTD4 was apparently metabolized within this period. Subsequent injections of LTD4 into the same sites demonstrated the development of tachyphylaxis with respect to whealing. This evidence suggests that LTD4 cannot mediate sustained inflammation. The injections of LTD4 caused neither pain nor itching. In conclusion, the elucidated properties point to LTD4 as a possible mediator of microvascular changes during acute inflammation.  
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  Corporate Author Thesis  
  Impact Factor 07,216 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bisgaard, H.  
  ISSN 0022-202X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:3805752 Approved no  
  Call Number Serial 299  
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