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Author Bisgaard, H.; Damkjaer Nielsen, M.; Andersen, B.; Andersen, P.; Foged, N.; Fuglsang, G.; Host, A.; Leth, C.; Pedersen, M.; Pelck, I. url  openurl
  Title Adrenal function in children with bronchial asthma treated with beclomethasone dipropionate or budesonide Type Journal Article
  Year (down) 1988 Publication The Journal of Allergy and Clinical Immunology Abbreviated Journal J Allergy Clin Immunol  
  Volume 81 Issue 6 Pages 1088-1095  
  Keywords Adolescent; *Adrenal Cortex Function Tests; Androstenedione/blood; Asthma/drug therapy/*physiopathology/urine; Beclomethasone/adverse effects/*therapeutic use; Budesonide; Child; Circadian Rhythm/drug effects; Clinical Trials as Topic; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hydrocortisone/blood/urine; Male; *Pituitary-Adrenal Function Tests; Pregnenediones/adverse effects/*therapeutic use; Prospective Studies; Random Allocation  
  Abstract The effect of inhaled beclomethasone dipropionate and budesonide on the adrenal function was studied in 30 children (aged 7 to 15 years) with mild bronchial asthma. The trial was designed as a prospective double-blind parallel study of the effect of stepwise increase of either beclomethasone dipropionate or budesonide from 200 micrograms through 400 micrograms, to 800 micrograms daily in three consecutive periods of 4 weeks. At the end of each period, the adrenal stress response was evaluated by measurements of serum cortisol and androstenedione during a short adrenocorticotropic hormone test. The unstimulated diurnal production of glucocorticosteroids was assessed by measurements of free cortisol in 24-hour urine samples. Free cortisol in urine was found a valid measure of the total diurnal excretion of cortisol metabolites, since it exhibited a good correlation to the fractional cortisol metabolites measured by gas chromatography. The adrenal response to adrenocorticotropic hormone stimulation was unaffected by treatment or dose. The unstimulated diurnal production of glucocorticosteroids demonstrated a highly significant dose-related suppression in response to the inhaled steroids. No significant difference was found between the two topical steroids (probability value 5.3%), and yet the suppression was apparent in the group of children treated with beclomethasone dipropionate but not in the group of children treated with budesonide. Further studies are desirable in order to ascertain whether budesonide offers an improved ratio between beneficial anti-inflammatory effect and unwanted systemic activity.  
  Address Department of Pediatrics, Rigshospitalet, Copenhagen, Denmark  
  Corporate Author Thesis  
  Impact Factor 11,476 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Pelck, I.  
  ISSN 0091-6749 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:3288682 Approved no  
  Call Number Serial 298  
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