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Author Bisgaard, H.; Olsson, P.; Bende, M. url  openurl
  Title Effect of leukotriene D4 on nasal mucosal blood flow, nasal airway resistance and nasal secretion in humans Type Journal Article
  Year (down) 1986 Publication Clinical Allergy Abbreviated Journal Clin Allergy  
  Volume 16 Issue 4 Pages 289-297  
  Keywords Administration, Topical; Adolescent; Adult; Airway Resistance/*drug effects; Dose-Response Relationship, Drug; Histamine Release/drug effects; Humans; Middle Aged; Nasal Mucosa/*blood supply/drug effects/physiopathology/secretion; Regional Blood Flow/drug effects; Respiratory Hypersensitivity/physiopathology; Rheology; SRS-A/administration & dosage/immunology/*pharmacology; Ultrasonography  
  Abstract The possible role of leukotriene D4 (LTD4) in nasal allergy was investigated in healthy volunteers. Nasal blood flow, nasal airway resistance, nasal discharge and nasal itching and sneezing were examined. LTD4 was found to induce a dose-response related increase in nasal mucosal blood flow as measured by laser-Doppler flowmetry. Histamine exhibited similar effects on blood flow in the same concentration range. Nasal airway resistance as recorded by rhinomanometry, increased in a dose-related manner after topical LTD4. Nasal secretion was obtained by nasal lavage and estimated from a dilution principle. Topical LTD4 did not increase the amount of nasal secretion, whereas a dose-related increase was found after topical histamine. LTD4 did not cause itching, sneezing or other irritative symptoms. In conclusion, LTD4 may play a role in nasal allergy by increasing blood flow and nasal airway resistance. Itching, sneezing and discharge, however, are apparently not caused by LTD4 but can be accounted for by the release of histamine or other mediators.  
  Address  
  Corporate Author Thesis  
  Impact Factor First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Bende, M.  
  ISSN 0009-9090 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:2427255 Approved no  
  Call Number Serial 296  
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