toggle visibility Search & Display Options

Select All    Deselect All
 |   | 
Details
   print
  Record Links
Author Bisgaard, H.; Kristensen, J.K.; Sondergaard, J. url  openurl
  Title A new technique for ranking vascular corticosteroid effects in humans using laser-Doppler velocimetry Type Journal Article
  Year (down) 1986 Publication The Journal of Investigative Dermatology Abbreviated Journal J Invest Dermatol  
  Volume 86 Issue 3 Pages 275-278  
  Keywords Adrenal Cortex Hormones/*pharmacology; Adult; Aged; Dose-Response Relationship, Drug; Female; Humans; Lasers; Male; Middle Aged; Prostaglandins/biosynthesis; Rheology; Skin/*blood supply/drug effects  
  Abstract By combining laser-Doppler velocimetry with reactive hyperemia, induced by arterial occlusion of 4-min duration we have established a simple and atraumatic new ranking technique for assessing steroid potency. The experiments were performed in 19 healthy volunteers. Budesonide (Preferid) and placebo (vehicle) were applied under occlusion on the flexor aspect of the forearm for 2, 24, and 48 h. Blood flow was measured with a laser-Doppler flowmeter before and after arterial occlusion with a blood pressure cuff on the upper arm. The induced reactive hyperemia reaction was measured planimetrically on the registered curves. The steroid preparation caused a significant reduction of the hyperemia closely related to the application time. The reduction of the hyperemia was confirmed using the atraumatic 133Xe washout technique. In another group, hydrocortisone, hydrocortisone-butyrate (Locoid), budesonide (Preferid), and klobetasol (Dermovat) applied under occlusion for 1 h were compared. A significant dose-response relation corresponding to the expected rank-order efficacy was revealed. In 10 experiments, pretreatment with 50 mg indomethacin i.v. resulted in a significant reduction of the hyperemia reaction. As a hypothesis we therefore suggest that the reactive hyperemia reaction amplifies the vascular events and unmasks steroid-induced inhibition of the synthesis of arachidonic acid metabolites.  
  Address  
  Corporate Author Thesis  
  Impact Factor 07,216 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Sondergaard, J.  
  ISSN 0022-202X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:2943820 Approved no  
  Call Number Serial 295  
Permanent link to this record
Select All    Deselect All
 |   | 
Details
   print

Save Citations:
Export Records: