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Author Bisgaard, H.; Kristensen, J.K. url  openurl
  Title Leukotriene B4 produces hyperalgesia in humans Type Journal Article
  Year (down) 1985 Publication Prostaglandins Abbreviated Journal Prostaglandins  
  Volume 30 Issue 5 Pages 791-797  
  Keywords Humans; Hyperalgesia/*chemically induced; Hyperesthesia/*chemically induced; Leukotriene B4/*pharmacology; Pain/physiopathology; Sensory Thresholds/drug effects  
  Abstract During inflammation, pain receptors are sensitized by inflammatory mediators causing hyperalgesia. Leukotriene B4 (LTB4) is a potent chemoattractant for polymorphonuclear leukocytes in humans in vivo. In the present study we have demonstrated a reduction of the pain threshold in humans after intracutaneous deposition of LTB4. The pain threshold was quantitated by the “Marstock” method in which the testsubject reversed the direction of the temperature change of a thermostimulator whenever a painful temperature was reached. This enabled a quantitative description of the persons pain sensibility. After intracutaneous infiltration of LTB4 (10 microM) a highly significant decrease in the pain threshold could be detected as compared to control with a maximum effect between 6 and 24 h. The decrease in the pain threshold amounted to less than 15% when compared to control and corresponds with the published kinetics of the influx of polymorphonuclear leukocytes. These results support the hypothesis that LTB4 produces hyperalgesia indirectly through recruitment of polymorphonuclear leukocytes and not via a direct effect on the pain receptors. Inhibition of the lipoxygenase might be an advantageous adjunct to the effect of the Non Steroidal Anti-Inflammatory Drugs.  
  Address  
  Corporate Author Thesis  
  Impact Factor 02,377 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Kristensen, J.K.  
  ISSN 0090-6980 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:3001832 Approved no  
  Call Number Serial 290  
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