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Author Bisgaard, H.; Ford-Hutchinson, A.W.; Charleson, S.; Taudorf, E. url  openurl
  Title Production of leukotrienes in human skin and conjunctival mucosa after specific allergen challenge Type Journal Article
  Year (down) 1985 Publication Allergy Abbreviated Journal Allergy  
  Volume 40 Issue 6 Pages 417-423  
  Keywords Adolescent; Adult; Conjunctiva/*immunology; Female; Humans; Hypersensitivity/*physiopathology; Leukotriene B4/metabolism; Male; Radioimmunoassay; SRS-A/*immunology/metabolism; Skin/*immunology; Tears/immunology  
  Abstract The production of leukotrienes has been monitored in tear fluids from subjects following a conjunctival provocation test, and skin blister fluids following initiation of a Prausnitz-Kustner reaction. In tear fluids elevated levels of leukotriene C4 (LTC4)-immunoreactive material were measured following allergen challenge as compared to control tear fluid obtained by mechanical or reflex stimulation. Analysis by high performance liquid chromatography indicated the presence of LTC4, LTD4 and LTE4. In the skin, significantly elevated levels of LTC4-immunoreactive material were measured following allergen challenge in the Prausnitz-Kustner reaction. HPLC analysis indicated the presence of both LTC4 and LTD4. LTB4 immunoreactive material was detected both in the tear fluid and the skin tissue fluid. However, no significant increase occurred in either tissue after the allergic reactions. These results indicate that the SRS-A leukotrienes are released in vivo in man following allergen challenge, and indicate these mediators may be important in human allergic diseases.  
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  Corporate Author Thesis  
  Impact Factor 06,028 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Taudorf, E.  
  ISSN 0105-4538 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:2996379 Approved no  
  Call Number Serial 289  
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