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Author Bisgaard, H.; Groth, S.; Madsen, F. url  openurl
  Title Bronchial hyperreactivity to leucotriene D4 and histamine in exogenous asthma Type Journal Article
  Year (down) 1985 Publication BMJ Abbreviated Journal BMJ  
  Volume 290 Issue 6480 Pages 1468-1471  
  Keywords Adolescent; Adult; Airway Resistance/drug effects; Asthma/*immunology/physiopathology; Bronchi/*drug effects; Clinical Trials as Topic; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Histamine/*pharmacology; Humans; Male; Peak Expiratory Flow Rate; SRS-A/*pharmacology; Vital Capacity  
  Abstract Reactivity of the small and large airways to inhaled leucotriene D4, one of the leucotrienes that constitute slow reacting substance of anaphylaxis, was studied in eight patients with exogenous asthma and nine healthy subjects with no history of atopy. Non-cumulative dose response relations were constructed for leucotriene D4 in a randomised, double blind set up. Reactivity to the leucotriene was compared with reactivity to histamine in the two groups. Both groups reacted to leucotriene D4 with significant airway obstruction evident in forced expiratory volume in one second (FEV1), peak expiratory flow rate, maximal expiratory flow rate at 30% of forced vital capacity estimated from a partial flow volume curve initiated at 50% of vital capacity (V30), and an increase in volume of trapped gas. The airways of the patients were significantly (p less than 0.01) more reactive to leucotriene D4 than those of the controls. The differences were in order of magnitude, 10(2)-10(3) for FEV1 but only about 15 for V30 (p less than 0.05). The hyperreactivity of the airways of the asthmatic subjects to leucotriene D4 was comparable to that to histamine. Inhalation of leucotriene D4 caused pronounced dyspnoea only among the patients. The findings suggest a role for leucotriene D4 in human bronchial asthma.  
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  Corporate Author Thesis  
  Impact Factor 17,445 First Author Bisgaard, H. Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Senior Author Madsen, F.  
  ISSN 0267-0623 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:3922535; PMCID:PMC1415696 Approved no  
  Call Number Serial 288  
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